Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (Al). [PDF]
PLoS ONE, 2012 Renal involvement is a frequent consequence of plasma cell dyscrasias. The most common entities are light chain amyloidosis, monoclonal immunoglobulin deposition disease and myeloma cast nephropathy.
Marina Ramirez-Alvarado +7 more
doaj +1 more source
Misdiagnosis of hereditary amyloidosis as AL (Primary) amyloidosis [PDF]
, 2002 Background: Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes encoding transthyretin, fibrinogen A -chain, lysozyme, or apolipoprotein A-I, is thought to be extremely rare and is not routinely included in the differential ...
Booth, D.R. +7 more
core
IgG‐Secreting Lymphoplasmacytic Lymphoma Presenting With Massive Kidney Infiltration
Clinical Case Reports, Volume 13, Issue 11, November 2025.ABSTRACT Various factors related to lymphoplasmacytic lymphoma (LPL) can lead to kidney complications; however, LPL‐related kidney complications are not as well‐described as those with multiple myeloma. Here, we report a case of IgG‐secreting LPL presenting with acute kidney injury owing to direct tumor infiltration.
Yuichi Nakamura +9 more
wiley +1 more source
Aryl Hydrocarbon Receptor in Health and Disease
MedComm, Volume 6, Issue 11, November 2025.Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li +11 more
wiley +1 more source
Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma [PDF]
, 2019 The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity.
Behrens, Emily +3 more
core
Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics
Alimentary Pharmacology &Therapeutics, Volume 62, Issue 9, Page 901-919, November 2025.Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen +20 more
wiley +1 more source
Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine.
Blood, 2018 TO THE EDITOR: Systemic amyloid light-chain amyloidosis (AL) is characterized by deposition of misfolded immunoglobulin light chains within organs. AL with an immunoglobulin M (IgM) monoclonal protein (IgM-AL) accounts for 5% to 7% of AL and exhibits ...
R. Manwani +13 more
semanticscholar +1 more source
Multiple Myeloma : an update on disease biology and therapy [PDF]
, 2004 Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Cook, Rachel J., Dingli, David
core
Monoclonal gammopathy of undetermined significance : natural course and comorbidities [PDF]
, 2017 Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by an overproduction of monoclonal immunoglobulins.
Lindqvist, Ebba K
core +1 more source