Results 71 to 80 of about 8,373 (204)
Journal of Medical Science, 2016 Amyloidosis is a heterogeneous group of disorders associated with pathological deposition of amyloid. We can recognize two major categories of amyloidosis: primary (AL) and secondary (AA) type.
Agnieszka Danuta Gaczkowska +2 more
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Barriers to Small Molecule Drug Discovery for Systemic Amyloidosis
Molecules, 2021 Inhibition of amyloid fibril formation could benefit patients with systemic amyloidosis. In this group of diseases, deposition of amyloid fibrils derived from normally soluble proteins leads to progressive tissue damage and organ failure.
Gareth J. Morgan
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The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Virtual Screening for Promising Kinetic Stabilizers of Light Chains in Immunoglobulin Light Chain Amyloidosis Through Drug Repurposing [PDF]
, 2023 Jonas Jeppesen, Casper Steinmann
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European Journal of Haematology, Volume 116, Issue 3, Page 226-234, March 2026.ABSTRACT Response assessment during treatment of multiple myeloma (MM) typically relies on immunofixation and serum electrophoresis. However, low levels of IgG and especially IgA paraprotein are difficult to quantify reliably. The Hevylite Assay quantifies the kappa and lambda fractions of IgG and IgA separately and is useful to determine response to ...
Tim Richardson +125 more
wiley +1 more source
ATTR Variant Amyloidosis in Patients with Dysphagia
Surgeries, 2023 Amyloidosis is a rare disease characterized by the accumulation of misfolded extracellular proteins in various organs. Over 30 precursor proteins have been identified that can form amyloid deposits in different parts of the body.
Christina Hui Lee Ng +2 more
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The clinical characteristics of immunoglobulin light chain amyloidosis in Chinese population: A systematic scoping review [PDF]
, 2021 Chengcheng Fu +4 more
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Aggregate, Volume 7, Issue 2, February 2026.Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo +7 more
wiley +1 more source
Primary (AL) Amyloidosis Following COVID‐19 Infection: A Case Report
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Primary (AL) amyloidosis is a rare systemic disorder caused by extracellular deposition of monoclonal immunoglobulin light chains, resulting in multi‐organ dysfunction. SARS‐CoV‐2 infection may induce persistent inflammatory and immune dysregulation, potentially promoting amyloid formation, although clinical evidence is limited, making the ...
Nasrin Gholami +4 more
wiley +1 more source
Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego +7 more
wiley +1 more source