Results 11 to 20 of about 411,227 (271)
Validation of Roche immunoassay for severe acute respiratory coronavirus 2 in South Africa
Southern African Journal of Infectious Diseases, 2021 Background: Serology testing is an important ancillary diagnostic to the reverse transcriptase polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Jurette S. Grove +12 more
doaj +1 more source
Open Medicine, 2021 Hepatitis A virus immunoglobulin M (HAV-IgM) is often used to diagnose acute hepatitis A virus (HAV) infection serologically. However, false-positive test results can interfere with the diagnosis.
Tan Youwen, Chen Li
doaj +1 more source
Frontiers in Immunology, 2022 IntroductionImmunoglobulins (Igs) play a pivotal role in host defense and prevention of pneumonia. Aging influences serum Ig levels, but the association between Igs and pneumonia in community-dwelling older individuals remains unknown.
Samer R. Khan +16 more
doaj +1 more source
Characterization of B1-cells during experimental leukomogenesis
Вопросы вирусологии, 2020 Background. Bovine leukemia causes a significant polyclonal expansion of CD5+ , IgM+ B lymphocytes, known as persistent lymphocytosis (PL), in approximately 30% of infected cattle.
I. Yu. Ezdakova +3 more
doaj +1 more source
Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]
, 2021 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv +1 more source
Diagnosis of toxoplasmosis by joint detection of immunoglobulin A and immunoglobulin M [PDF]
Journal of Clinical Microbiology, 1997 An indirect immunofluorescence test with total anti-human immunoglobulin conjugate (IgG,A,M-IIF) can be used for joint detection of immunoglobulin A (IgA) and IgM antibodies, provided serum IgG is previously absorbed with anti-human IgG. To determine the validity of the IgG,A,M-IIF assay with absorbed sera, the results obtained were compared with those
Gloria Griemberg +2 more
openaire +3 more sources
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Toxoplasmosis in immunoglobulin M-suppressed mice [PDF]
Infection and Immunity, 1982 Mice challenged with a pathogenic strain of Toxoplasma gondii develop fatal infections. However, if such mice are initially treated with sulfadiazine (SD), they develop immunity and survive with chronic infections. The role of antibody (Ab) in establishing protective immunity against acute parasitemias and in maintaining chronic infections was ...
Frenkel, J K, Taylor, D W
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Update on the hyper immunoglobulin M syndromes [PDF]
British Journal of Haematology, 2010 SummaryThe Hyper‐immunoglobulin M syndromes (HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination (CSR), with or without defects of somatic hypermutation (SHM). They can be classified as defects of signalling through CD40 causing both a humoral immunodeficiency and a susceptibility to ...
E. Graham Davies, Adrian J. Thrasher
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Case Reports in Nephrology and Dialysis, 2022 Immunotactoid glomerulopathy (ITG) occurs infrequently and is characterized by organized IgG containing deposits. It most usually manifests as a concomitant disease of a broad spectrum of oncologic entities.
Wolfgang Neukirchen +6 more
doaj +1 more source