Results 311 to 320 of about 585,196 (339)
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Pregnancy in immunoglobulin M nephropathy
Journal of Obstetrics and Gynaecology Research, 2017AbstractImmunoglobulin M nephropathy is an uncommon glomerular disease and a relatively less recognized clinico‐immunopathological entity in the domain of glomerulonephritis, often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis.
Meryem Hocaoglu +3 more
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Polymerization of human immunoglobulin M
Biochemistry, 1978The repolymerization of human IgM following mild reductive cleavage was studied as a model for intracellular polymer assembly. Repolymerization was found to require the presence of J chain and a disulfide exchanging system which could be furnished either intrinsically by the use of the monofunctional thiol mercaptoethylamine or extrinsically by the ...
Marian Elliott Koshland +1 more
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Purification of Immunoglobulin
AbstractThis unit describes two classical protocols for the purification of IgM ‐ dialysis of ascites fluid, tissue culture medium, or bioreactor supernatants against distilled water to precipitate pure IgM, and ammonium sulfate precipitation. Both protocols can be followed by size‐exclusion chromatography to obtain a highly purified product.
Richard Coico +3 more
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1985
Publisher Summary This chapter provides an overview of immunoglobulin M (IgM). IgM display, like other classes of Igs a wide variety of biological activities. IgM is also the first antibody class to be synthesized by the neonate and plays an important role in the pathogenesis of some autoimmune diseases.
David J. Hayzer, Jean-Claude Jaton
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Publisher Summary This chapter provides an overview of immunoglobulin M (IgM). IgM display, like other classes of Igs a wide variety of biological activities. IgM is also the first antibody class to be synthesized by the neonate and plays an important role in the pathogenesis of some autoimmune diseases.
David J. Hayzer, Jean-Claude Jaton
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Primary Selective Deficiency of Immunoglobulin M
Internal Medicine Journal, 1978Summary: Selective deficiency of IgM as a primary disorder is seldom encountered1–3, and the syndrome remains ill‐defined. It is generally accepted that for a diagnosis to be made, the serum IgM level should be consistently below 2 SD of normal, no other immunodeficiencies are present, and it is not secondary to other disease processes. This report of
G. M. Maxwell, Y. H. Thong
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Immunoglobulin-M purification — Challenges and perspectives
Biotechnology Advances, 2011Extensive research in the past two decades has led to the realization of Immunoglobulin-M (IgM) as a potential therapeutic and diagnostic agent. In order to fully exploit the potential of IgM, large quantities, in a highly pure and active form, must be available at low cost for performing clinical trials, characterization studies and quantitative ...
Kai-Chee Loh, Satyen Gautam
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Immunoglobulin M perception by FcμR
Nature, 2023L'immunoglobuline M (IgM) est le premier anticorps à émerger au cours du développement embryonnaire et de la réponse immunitaire humorale1. Les IgM peuvent exister sous plusieurs formes distinctes, y compris les IgM monomériques liées à la membrane dans le complexe du récepteur des cellules B (BCR), les IgM pentamériques et hexamériques dans le sérum ...
Yaxin Li +6 more
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Immunoglobulin G paraprotein cross-reactivity with immunoglobulin M measurement
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2008We report a case of IgG paraprotein cross-reactivity with IgM measurement in a patient with IgGκ multiple myeloma and associated IgA and IgM immune paresis. IgM measurements using a Beckman-Coulter Synchron LX IgM reagent initially gave unmeasurably low IgM concentrations (<0.3 g/L) but IgM quantitation using later batches of reagent gave IgM ...
Lian-King Lee, Robert C. Hawkins
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Immunoglobulin M as a vaccine adjuvant
Medical Hypotheses, 2011Vaccines are effective in preventing disease by stimulating the immune system and sustaining an immune response towards eradication of pathogens and diseased cells. However, designing successful vaccines is not always straightforward. For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated, primarily by adjuvants, towards a
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Structure of Human Immunoglobulin M
The Journal of Immunology, 1968Summary A 10.6 S fragment with an approximate molecular weight of 320,000, which represented the Fc portion of the human IgM was isolated by digesting the IgM in the absence of cysteine with activated papain. Comparison of antigenic properties, amino acid composition and carbohydrate content of this fragment with those of the Fc fragment
Tadamitsu Kishimoto +2 more
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