Results 51 to 60 of about 423,364 (313)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

6th International Immunoglobulin Symposium: poster presentations [PDF]

, 2009
The posters presented at the 6th International Immunoglobulin Symposium covered a wide range of fields and included both basic science and clinical research.
van Schaik, I N, Yuki, Nobuhiro, Winkelmann, A, N. Yuki, A. Durandy, Käsermann, F., Durandy, Anne, Quinti, I., Späth, P., Fernandez-Cruz, E, Durandy, A., Danieli, Maria Giovanna, A. Winkelmann, Cantoni, N, M. G. Danieli, Kaesermann, F., Käsermann, F, Helbert, M., Späth, P, Späth, Paul, J. Bayry, P. Spath, van Schaik, I.N., Fernández-Cruz, Eduardo, QUINTI, Isabella, Quinti, I, Kaveri, S. V., Durandy, A, Bussel, J B, Bayry, J, I. N. Van Schaik, Cantoni, N., J. B. Bussel, Helbert, M, Peter Hh, Bussel, J.B., Winkelmann, A., Spaeth, P., R. Sorensen, Yuki, N, Peter, H.-H., Peter, Hans-Hartmut, van Schaik, I. N., Sorensen, R., Schaik, Ivo N. van, M. Helbert, Bayry, J., Yuki, N., Sorensen, R, Kaveri, S V, S. V. Kaveri, Salama, A., E. Fernandez Cruz, Salama, A, A. Salama, Kaveri, S.V., Fernandez-Cruz, E., Peter, H.H., Winkelmann, Aline, Danieli, M.G., Danieli, M. G., Danieli, M G, F. Kasermann, Helbert, Matthew, Peter, H-H, N. Cantoni, Bussel, J. B., Salama, Abdulgabar   +67 more
core   +1 more source

Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA

Frontiers in Immunology, 2023
IntroductionMZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it interacts with the tail piece of IgM and IgA heavy chain and promotes ...
Benjamin Geary, Bo Sun, Bo Sun, Ronak R. Tilvawala, Leonard Barasa, Konstantin Tsoyi, Ivan O. Rosas, Paul R. Thompson, I-Cheng Ho, I-Cheng Ho   +9 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Colostral Immunoglobulin G1 and Immunoglobulin M Concentrations on Immunoglobulin Absorption in Calves

Journal of Dairy Science, 1985
Twenty-three calves were fed colostrum at 110 ml/kg body weight divided into two feedings at 1 and 13 h of age. The concentrations of immunoglobulins were measured in the colostrum fed and in the calves' sera following colostrum feeding. Apparent efficiency of immunoglobulin absorption was calculated for each calf.
T E, Besser, A E, Garmedia, T C, McGuire, C C, Gay   +3 more
openaire   +2 more sources

Update on the hyper immunoglobulin M syndromes [PDF]

British Journal of Haematology, 2010
SummaryThe Hyper‐immunoglobulin M syndromes (HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination (CSR), with or without defects of somatic hypermutation (SHM). They can be classified as defects of signalling through CD40 causing both a humoral immunodeficiency and a susceptibility to ...
Davies, E Graham, Thrasher, Adrian J
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Seroprevalence of Cytomegalovirus and Associated Factors Among Preconception Women: A Cross-Sectional Nationwide Study in China

Frontiers in Public Health, 2021
Background: Cytomegalovirus seroconversion during pregnancy is common and has a substantial risk of congenital infection with longterm sequale. Screening during pregnancy or vaccination have not been shown to be effective for eliminating congenital ...
Qiongjie Zhou, Qiongjie Zhou, Qiaomei Wang, Haiping Shen, Yiping Zhang, Shikun Zhang, Xiaotian Li, Xiaotian Li, Ganesh Acharya, Ganesh Acharya   +9 more
doaj   +1 more source