Results 211 to 220 of about 89,290 (305)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Management of a Complex Orbital Post-transplantation Lymphoproliferative Disorder: A Case Report and Literature Review. [PDF]

In Vivo
Maruyama T, Hokama Y, Kishaba K, Kuninaka T, Kobayashi S, Nagamine H, Miyahira H, Tanaka K, Morichika K, Kawakami F, Tomita M, Wada N, Yogi A, Masuzaki H, Hamasaki T.   +14 more
europepmc   +1 more source

Spatially Selective Solvation Chemistry by Local Charge Enrichment for Stable Potassium‐Metal Anodes

Advanced Science, EarlyView.
A MoC/NC functional intermediate medium preferentially interacts with KFSI to reconstruct the interfacial solvation structure and form a KF‐rich inorganic SEI. The synergistic integration of the electronically insulating SEI and MoC/NC suppresses electron tunneling, enables fast and balanced K+/electron transport, and promotes uniform K deposition for ...
Lu‐Kang Zhao, Xi‐Ran Zhao, Zhimin Ding, Yu‐Hua Bian, Xuan‐Chen Wang, Dongdong Zhao, Yizhuo Zhao, Xuan‐Wen Gao, Zhaomeng Liu, Wen‐Bin Luo   +9 more
wiley   +1 more source

An update on the characterization of immunoglobulin loci in <i>Ambystoma mexicanum</i>. [PDF]

Front Immunol
Saint Remy-Hernández S, Pacheco-Olvera DL, Godoy-Lozano EE, Miguel-Ruiz J, Téllez-Sosa J, Valdovinos-Torres H, Rivas N, López-Macías C, Martínez-Barnetche J.   +8 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Alveolar soft part sarcoma in buccal mucosa of a young child. [PDF]

BMJ Case Rep
Kamble MM, Swain N, Pathak J, Nalband MR.   +3 more
europepmc   +1 more source

Laser‐Induced Periodic Phase‐Transition of 2D‐MoTe2 Nanograting Template for Frequency‐Shift Digital‐SERS Immunoassay of Autoimmune Disease

Advanced Science, EarlyView.
A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao, Lulu Cao, Xiaolin Sun, Qiang Wang, Zhiyang Xu, Tianrui Zhai, Yan Zhao, Yijian Jiang, Zhanguo Li, Yinzhou Yan   +9 more
wiley   +1 more source

Remission with residuals, but no cure. [PDF]

Blood Adv
Al-Sawaf O.
europepmc   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Gatm ablation disrupts spermatogenesis by impairing ribosome biogenesis and coupling defective steroid biosynthesis to immunoglobulin silencing. [PDF]

Front Cell Dev Biol
Li S, Chen L, Zhu M, Yang L, Wu H, Zhou X.   +5 more
europepmc   +1 more source