Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier +8 more
wiley +1 more source
Biomedical Papers, 2018 Background and Aims: Detection of oligoclonal IgG (o-IgG) in the cerebrospinal fluid (CSF) not found in serum is the principal laboratory test to support a diagnosis of multiple sclerosis.
Ondrej Dlouhy +4 more
doaj +1 more source
The partial sequence of two large peptides from the N-terminal half of heavy chains from normal rabbit immunoglobulin G [PDF]
, 1968 John J. Cebra +2 more
openalex +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi +6 more
wiley +1 more source
Characterisation of placental malaria in olive baboons (Papio anubis) infected with Plasmodium knowlesi H strain [PDF]
Int. J. Integ. Biol: Year 2012 Volume 9, Issue No. 2: 54 - 58, 2012 Pregnant women have increased susceptibility to malaria infection. In these women, malaria parasites are frequently found sequestered in the placental intervillous spaces, a condition referred to as placental malaria (PM). Placental malaria threatens the health of the mother and the child's life by causing still births and reduction in gestational age.
arxiv
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status Scale (EDSS) scores, magnetic resonance imaging (MRI) lesion counts, and ...
Antonia Bralić +13 more
wiley +1 more source
Serum levels of immunoglobulins in marasmic infants. [PDF]
, 1969 Shahenaz Najjar +2 more
openalex +1 more source
CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh +8 more
wiley +1 more source
Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization [PDF]
, 1968 Malcolm Turner, H. Bennich
openalex +1 more source