Late diagnosis of agammaglobulinemia in an 8-year-old boy
Pediatria i Medycyna Rodzinna, 2016 Chromosome X-linked Bruton agammaglobulinemia is classified as a primary immunodeficiency disorder. It is a genetic condition associated with a mutation in the BTK gene encoding tyrosine kinase.
Małgorzata Sopińska +4 more
doaj +1 more source
A computational study of the statistical mechanics of antibody-antigen conformations [PDF]
arXiv, 2004 We describe the representation of the chemical affinity between the antigen-combining site of the immunoglobulin molecule and the antigen molecule as the probability of the two molecules existing in a bound state. Our model is based on the identification of shape attractors in the configuration space for the joint antibody / antigen combining site ...
arxiv
The role of immunogenetic factors in the aetiology of pre-eclamptic toxaemia of human pregnancy [PDF]
, 1978 2 volume setThesis (M.D.) -- University of Adelaide, Dept.
Need, Jillian Ann
core +1 more source
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Nature, 2011 Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution.
X. Puente +63 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg +7 more
wiley +1 more source
THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE [PDF]
, 1969 Gerald M. Edelman +5 more
openalex +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier +8 more
wiley +1 more source
Microorganisms, 2019 Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor.
Ryan M. Moreno +2 more
doaj +1 more source
Energetic frustrations in protein folding at residue resolution: a simulation study of homologous immunoglobulin-like \b{eta}-sandwich proteins [PDF]
arXiv, 2017 Nonnative residual interactions have attracted increasing attention in recent protein folding researches. Experimental and theoretical investigations had been set out to catch nonnative contacts that might dominate key events in protein folding. However, energetic frustrations caused by nonnative inter-residue interactions are not systematically ...
arxiv
Immunoglobulins in Serum and Nasal Secretions Following Infection with Type 1 Parainfluenza Virus and Injection of Inactivated Vaccines [PDF]
, 1967 Charles B. Smith +2 more
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