Results 101 to 110 of about 1,287,734 (381)

Reproducing the Molecular Subclassification of Peripheral T-cell Lymphoma-NOS by Immunohistochemistry.

Blood, 2019
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell malignancies with approximately one-third of cases designated as PTCL-not otherwise specified (PTCL-NOS).
Catalina Amador, T. Greiner, Tayla B. Heavican, Lynette M. Smith, Karen Galvis, Waseem G Lone, Alyssa Bouska, F. d'Amore, Martin Bjerregård Pedersen, S. Pileri, C. Agostinelli, A. Feldman, A. Rosenwald, G. Ott, A. Mottok, K. Savage, L. de Leval, P. Gaulard, S. Lim, C. Ong, S. Ondrejka, J. Song, E. Campo, E. Jaffe, L. Staudt, L. Rimsza, J. Vose, D. Weisenburger, W. Chan, J. Iqbal   +29 more
semanticscholar   +1 more source

Immunohistochemistry of the Skin [PDF]

Laboratory Medicine, 2003
have presented a host of fungal, viral, and bacterial infections of the skin. In the last decade, immunohisto- chemistry has played an increasingly important role for routine diagnosis, prognosis, and research. The complexity of all skin disorders makes it imperative to understand IHC and the different dis- ciplines that are required by today's der ...
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Intratumoral Heterogeneity Reflects the Intertumoral Subtypes of Glioblastoma Multiforme: A Regional Immunohistochemistry Analysis

Frontiers in Oncology, 2020
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite extensive therapy the prognosis for GBM patients remains poor and the extraordinary therapy resistance has been attributed to intertumoral ...
Natalie Bergmann, C. Delbridge, J. Gempt, A. Feuchtinger, A. Walch, Lucas Schirmer, W. Bunk, T. Aschenbrenner, F. Liesche-Starnecker, J. Schlegel   +9 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. [PDF]

, 2018
Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar carcinoma continues to be a challenge.
Alves, Venancio Af, Cruise, Michael W, Ferrell, Linda, Gill, Ryan M, Graham, Rondell P, Greipp, Patricia T, Jain, Dhanpat, Jin, Long, Kakar, Sanjay, Kerr, Sarah E, Lam-Himlin, Dora, Longerich, Thomas, Nart, Deniz, Roberts, Lewis R, Roessler, Stephanie, Rustin, Jeanette G, Salaria, Safia N, Schirmacher, Peter, Solomon, David A, Sukov, William R, Terracciano, Luigi, Torbenson, Michael S, Wang, Xiaoke, Waterhouse, Emily, Yeh, Matthew M, Yilmaz, Funda, Zaid, Nida, Zreik, Riyam T   +27 more
core   +1 more source

Prognostic value of the expression and localization of cell proliferation and apoptosis markers in unicystic ameloblastomas

Scientific Reports
The aim of this study was to verify whether the expression of cell proliferation and apoptosis markers in different types of unicystic ameloblastoma (UA) is associated with the location of neoplastic cells.
Rebeca Vieira Costa, Karolyny Martins Balbinot, Gabriela Cristina Avertano Rocha da Silveira, Maria Sueli da Silva Kataoka, Silvio Augusto Fernandes de Menezes, Vanessa Morais Freitas, Ana Carolina Uchoa Vasconcelos, Adriana Etges, Victor Angelo Martins Montalli, Fabricio Passador Santos, Sérgio de Melo Alves Júnior, Ruy Gastaldoni Jaeger, João de Jesus Viana Pinheiro   +12 more
doaj   +1 more source

Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry

Journal of Clinical Pathology, 2016
Increased expression levels of KCNJ3 have been correlated with lymph node metastases and poor prognosis in patients with breast cancer, suggesting a prognostic role of KCNJ3.
Y. Ju, Ludmil B. Alexandrov, M. Gerstung, I. Martincorena, S. Nik-Zainal, Manasa Ramakrishna, Helen R Davies, E. Papaemmanuil, G. Gundem, A. Shlien, N. Bolli, S. Behjati, P. Tarpey, J. Nangalia, C. Massie, Adam P. Butler, J. Teague, G. Vassiliou, A. Green, Mingyuan Du, Ashwin Unnikrishnan, J. Pimanda, B. Teh, N. Munshi, M. Greaves, P. Vyas, A. E. Naggar, T. Santarius, V. P. Collins, Richard Grundy, Jack A. Taylor, D. Hayes, D. Malkin, Christopher S. Foster, A. Warren, H. Whitaker, D. Brewer, R. Eeles, Colin S. Cooper, D. E. Neal, T. Visakorpi, W. Isaacs, G. Bova, A. Flanagan, P. Futreal, A. Lynch, P. Chinnery, Ultan McDermott, Michael R. Stratton, Peter J. Campbell   +49 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source