Results 101 to 110 of about 1,221,475 (381)

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, Volume 19, Issue 5, Page 1371-1385, May 2025.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy

Biomedicines
Background: Radiation-induced liver disease (RILD) is a severe complication arising from radiotherapy, particularly when treating abdominal malignancies such as hepatocellular carcinoma.
Grigory Demyashkin, Mikhail Parshenkov, Sergey Koryakin, Polina Skovorodko, Vladimir Shchekin, Vladislav Yakimenko, Zhanna Uruskhanova, Dali Ugurchieva, Ekaterina Pugacheva, Sergey Ivanov, Petr Shegay, Andrey Kaprin   +11 more
doaj   +1 more source

Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma

The Journal of Pathology: Clinical Research, 2016
TP53 mutations are ubiquitous in high‐grade serous ovarian carcinomas (HGSOC), and the presence of TP53 mutation discriminates between high and low‐grade serous carcinomas and is now an important biomarker for clinical trials targeting mutant p53.
M. Köbel, A. Piskorz, Sandra Lee, S. Lui, Cécile Lepage, F. Marass, N. Rosenfeld, Anne-Marie Mes Masson, J. Brenton   +8 more
semanticscholar   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]

, 2019
Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E, Karlen, Sarah J, Miller, Eric B, Ronning, Kaitryn E   +3 more
core   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Prognostic value of the expression and localization of cell proliferation and apoptosis markers in unicystic ameloblastomas

Scientific Reports
The aim of this study was to verify whether the expression of cell proliferation and apoptosis markers in different types of unicystic ameloblastoma (UA) is associated with the location of neoplastic cells.
Rebeca Vieira Costa, Karolyny Martins Balbinot, Gabriela Cristina Avertano Rocha da Silveira, Maria Sueli da Silva Kataoka, Silvio Augusto Fernandes de Menezes, Vanessa Morais Freitas, Ana Carolina Uchoa Vasconcelos, Adriana Etges, Victor Angelo Martins Montalli, Fabricio Passador Santos, Sérgio de Melo Alves Júnior, Ruy Gastaldoni Jaeger, João de Jesus Viana Pinheiro   +12 more
doaj   +1 more source

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +2 more sources

Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips

Journal of Pathology and Translational Medicine, 2016
Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the ...
So-Woon Kim, Jin Roh, Chan-Sik Park
semanticscholar   +1 more source