Results 331 to 340 of about 1,221,475 (381)

Tumor Cell Counting Using an Image Analysis Program for MIB-1 Immunohistochemistry

, 1997
Mitsunobu Ide, Minoru Jimbo, Masaaki Yamamoto, Osami Kubo   +3 more
openalex   +2 more sources

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

Hybrid nerve sheath tumor of the spinal canal and neurofibromatosis-2, where the twain shall meet-a case report and review of literature. [PDF]

J Med Case Rep
Nayak Manel D, Thaker S, Vasudevan G, Menon G.   +3 more
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Efficacy of Quality and Quantity media-cultured mononuclear cells for promoting peripheral nerve regeneration in mouse model. [PDF]

PLoS One
Akaranuchat N, Chruewkamlow N, Sathan-Ard C, Phutthakunphithak P, Tapechum S, Ruangsetakit C, Sermsathanasawadi N.   +6 more
europepmc   +1 more source

NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The N‐acetyltransferase‐10 (NAT10)‐mediated mRNA N4‐acetylcytidine modification enhances the stability of CXCL2 and KLF5 mRNA. Then, secreted CXCL2 promotes M2 macrophage polarization and oncostatin M secretion, activating NAT10 expression via STAT3 signaling.
Chen Chen, Zhangding Wang, Qingfeng Lin, Mengmeng Li, Lei Xu, Yao Fu, Xiaoya Zhao, Zhuang Ma, Jiawen Xu, Shimeng Zhou, Mingyue Zhang, Yun Qian, Linsen Bao, Bo Wang, Meng Wang, Qingqing Ding, Qiang Wang, Shouyu Wang   +17 more
wiley   +1 more source

Reactive oxygen species-related oxidative changes are associated with splenic lymphocyte depletion in Ebola virus infection. [PDF]

Npj Imaging
Mani V, Chu WT, Yang HJ, Morris CP, Laux J, Byrum R, Cooper K, Liu DX, Wang H, Johnson C, Hadley K, Bernbaum JG, Hart R, Anthony SM, Marketon AE, Bernbaum-Cutler R, Pahar B, Worwa G, Kuhn JH, Crozier I, Calcagno C, Gale E.   +21 more
europepmc   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Advanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang   +10 more
wiley   +1 more source

Perinephric myxoid pseudotumor of fat: the first case report in China with an updated literature review. [PDF]

Front Oncol
Yang YH, Zhang YM, Liu AH, Luo GC, Liu ZJ, Xie JW.   +5 more
europepmc   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source