Results 111 to 120 of about 9,954 (301)

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
doaj  

Harnessing Immunoinformatics for Precision Vaccines:Designing Epitope-Based Subunit Vaccines against Hepatitis E Virus [PDF]

Background/Objectives: Hepatitis E virus (HEV) is an RNA virus recognized to be spread mainly by fecal-contaminated water. Its infection is known to be a serious threat to public health globally, mostly in developing countries, in which Africa is one of ...
Ajani, Olumide Faith, Ajayi, Ayodeji Folorunsho, Ariyo, Olumuyiwa Elijah, Bamigboye, Comfort Olukemi, Dairo, Emmanuel Oluwatobi, Iwalokun, Bamidele Abiodun, Jimah, Esther Moradeyo, Oladipo, Elijah Kolawole, Oloke, Julius Kola, Onile, Olugbenga Samson, Onyeaka, Helen, Oyawoye, Olubukola Monisola   +11 more
core   +1 more source

iVax: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines [PDF]

, 2015
Computational vaccine design, also known as computational vaccinology, encompasses epitope mapping, antigen selection and immunogen design using computational tools.
De Groot, Anne S., Gutierrez, Andres H., Kibria, Farzana, Liu, Rui, Martin, Rebecca, Martin, William, Moise, Leonard, Tassone, Ryan, Terry, Francis   +8 more
core   +2 more sources

Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies

BMC Biotechnology
Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and non-human primates.
F. Al-Zayadi, Ali S. Shakir, A. Kareem, A. Ghasemian, Esmaeil Behmard   +4 more
semanticscholar   +1 more source

Design of Innovative Divalent Cj1621 and CjaA Multiepitope mRNA‐Based Vaccine Against Foodborne Campylobacter jejuni Using In Silico Approaches

Veterinary Medicine International, Volume 2025, Issue 1, 2025.
Campylobacter jejuni is one of the main causes of gastroenteritis in human and animals worldwide. Emergence of antibiotic resistance in microorganisms increased the need to develop new types of vaccines. The present study aimed to design novel multiepitope mRNA vaccine against Campylobacter jejuni using immunoinformatics tools.
Dhama Al-Sallami, Amjed Alsultan, Amir Hani Raziq, Behrooz Sadeghi Kalani, Simon R. Clarke, Sumanta Nandi   +5 more
wiley   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
doaj  

Design of a multi-epitope vaccine against goatpox virus using an immunoinformatics approach

Frontiers in Cellular and Infection Microbiology
Introduction Goatpox, a severe infectious disease caused by goatpox virus (GTPV), leads to enormous economic losses in the livestock industry. Traditional live attenuated vaccines cause serious side effects and exist a risk of dispersal. Therefore, it is
Qinqin Long, Min Wei, Yuting Wang, Feng Pang   +3 more
semanticscholar   +1 more source

Molecular Analysis and Bioinformatics Assessment of Full‐Length L1 Gene of Bovine Papillomavirus Type‐1 as a Potential DNA Vaccine Study

Veterinary Medicine International, Volume 2025, Issue 1, 2025.
Background: Papillomaviruses (PVs) infect animals and humans and are linked to 27%–30% of cancers. The L1 protein is a cornerstone in bovine PVs (BPVs), being the main components of the viral capsid and playing pivotal roles in infectivity and antigenicity.
Hassan Hadi Abdul-Zahra, Yahia I. Khudhair, Husam Raheem Al-Hraishawi, Mahmoud Elhaig   +3 more
wiley   +1 more source

Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus

Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati, Pooja Malik, Astha Sinha, Honey Yadav, Yachna K. Jaiwal, Yogesh K. Ahlawat, Darshna Chaudhary, Ranjana Jaiwal, Nisha Sharma, Pawan K. Jaiwal, Vijay K. Chattu   +10 more
wiley   +1 more source

IMGT-Choreography for immunogenetics and immunoinformatics.

In silico biology, 2005
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system ...
Lefranc, Marie-Paule, Clément, Olivier, Kaas, Quentin, Duprat, Elodie, Chastellan, Patrick, Coelho, Isabelle, Combres, Kora, Ginestoux, Chantal, Giudicelli, Véronique, Chaume, Denys, Lefranc, Gérard   +10 more
openaire   +2 more sources