ImmunoInformaticsCD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing
Christophe Arpin +2 more
doaj +1 more source
Is the vaccination-induced B cell receptor repertoire predictable?
ImmunoInformaticsVaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson +4 more
doaj +1 more source
Epitope-Based Peptide prediction of vaccine against European bat lyssaviruses type 2 Glycoprotein G with Immunoinformatic Approach [PDF]
, 2021 Manal Abdalla Gumaa +5 more
openalex +1 more source
Challenges for the immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era
ImmunoInformaticsFor over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has been widely supported by the research community. The principles behind the human nomenclatures were then
Andrew M. Collins +5 more
doaj +1 more source
Kernel methods in genomics and computational biology
, 2005 Support vector machines and kernel methods are increasingly popular in genomics and computational biology, due to their good performance in real-world applications and strong modularity that makes them suitable to a wide range of problems, from the ...
Vert, Jean-Philippe
core +1 more source
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma [PDF]
, 2018 Background: Cancer mutations generate novel (neo-)peptides recognised by T cells, but the determinants of recognition are not well characterised. The difference in predicted class I major histocompatibility complex (MHC-I) binding affinity between wild ...
Ghorani, E +7 more
core
Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2 [PDF]
, 2020 Esmaeil Behmard +3 more
openalex +1 more source
Immunoinformatics: Implications on Reverse Vaccinology
Immunochemistry & Immunopathology, 2017 One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine [1]. Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease [2].
openaire +1 more source
Highly conserved regions in Ebola virus RNA dependent RNA polymerase may be act as a universal novel peptide vaccine target: a computational approach [PDF]
, 2015 Afrin Sultana Chowdhury +4 more
core +1 more source