Results 111 to 120 of about 9,954 (301)
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle+11 more
doaj
Harnessing Immunoinformatics for Precision Vaccines:Designing Epitope-Based Subunit Vaccines against Hepatitis E Virus [PDF]
Background/Objectives: Hepatitis E virus (HEV) is an RNA virus recognized to be spread mainly by fecal-contaminated water. Its infection is known to be a serious threat to public health globally, mostly in developing countries, in which Africa is one of ...
Ajani, Olumide Faith+11 more
core +1 more source
iVax: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines [PDF]
Computational vaccine design, also known as computational vaccinology, encompasses epitope mapping, antigen selection and immunogen design using computational tools.
De Groot, Anne S.+8 more
core +2 more sources
Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies
Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and non-human primates.
F. Al-Zayadi+4 more
semanticscholar +1 more source
Campylobacter jejuni is one of the main causes of gastroenteritis in human and animals worldwide. Emergence of antibiotic resistance in microorganisms increased the need to develop new types of vaccines. The present study aimed to design novel multiepitope mRNA vaccine against Campylobacter jejuni using immunoinformatics tools.
Dhama Al-Sallami+5 more
wiley +1 more source
Improving immunovirotherapies: the intersection of mathematical modelling and experiments
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland+3 more
doaj
Design of a multi-epitope vaccine against goatpox virus using an immunoinformatics approach
Introduction Goatpox, a severe infectious disease caused by goatpox virus (GTPV), leads to enormous economic losses in the livestock industry. Traditional live attenuated vaccines cause serious side effects and exist a risk of dispersal. Therefore, it is
Qinqin Long+3 more
semanticscholar +1 more source
Background: Papillomaviruses (PVs) infect animals and humans and are linked to 27%–30% of cancers. The L1 protein is a cornerstone in bovine PVs (BPVs), being the main components of the viral capsid and playing pivotal roles in infectivity and antigenicity.
Hassan Hadi Abdul-Zahra+3 more
wiley +1 more source
Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati+10 more
wiley +1 more source
IMGT-Choreography for immunogenetics and immunoinformatics.
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system ...
Lefranc, Marie-Paule+10 more
openaire +2 more sources