Results 171 to 180 of about 880,908 (352)

Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm

Frontiers in Oncology
An array of published cell-based and small animal studies have demonstrated a variety of exposures of cancer cells or experimental carcinomas to electromagnetic (EM) wave platforms that are non-ionizing and non-thermal.
Mark M. Fuster, Mark M. Fuster, Mark M. Fuster, Mark M. Fuster   +3 more
doaj   +1 more source

Immunoregulatory factors derived from human tumors. I. Immunologic and biochemical characterization of factors that suppress lymphocyte proliferative and cytotoxic responses in vitro. [PDF]

, 1982
Jack A. Roth, Elizabeth A. Grimm, Rajat Gupta, Robert S. Ames   +3 more
openalex   +1 more source

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

Advanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim, Mujin Lee, Bohwa Han, Jinho Kim, Duck Cho, Junsang Doh, Aram J. Chung   +6 more
wiley   +1 more source

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

npj Vaccines
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global ...
Christina A. Rostad, Inci Yildirim, Carol Kao, Jumi Yi, Satoshi Kamidani, Etza Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E. Gelber, Robert A. Johnson, Sujin Lee, Kristal Maner-Smith, Steven Bosinger, Eric A. Ortlund, Xuemin Chen, Larry J. Anderson, Jens Wrammert, Mehul Suthar, Nadine Rouphael, Evan J. Anderson   +26 more
doaj   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene [PDF]

, 1998
Sebastian Finke, Beate Trojaneck, Petja Lefterova, Markus Csipai, Ernst Wagner, Ralf Kircheis, Andreas Neubauer, D. Huhn, B. Wittig, IGH Schmidt-Wolf   +9 more
openalex   +1 more source

Gut regulatory T cells mediate immunological tolerance inSalmonella-infected superspreader hosts by suppressing cytotoxic activity of T cells [PDF]

, 2021
LM Massis, Sarah Ruddle, SM Brewer, Ruth Schade, R Narasimhan, JD Honeycutt, Trung H. M. Pham, Joy A. McKenna, SW Brubaker, Phoom Chairatana, Jessica A. Klein, Mar Margalef-Català, MR Amieva, JG Vilches-Moure, DM Monack   +14 more
openalex   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Immunological changes in simian immunodeficiency virus (SIVagm)-infected African green monkeys (AGM): expanded cytotoxic T lymphocyte, natural killer and B cell subsets in the natural host of SIVagm

, 2002
Edgar Holznagel, Stephen Norley, Silke Holzammer, Cheick Coulibaly, Reinhard Kurth   +4 more
openalex   +1 more source

Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event

Advanced Science, EarlyView.
Lyme disease is caused by vascular dissemination of the bacteria Borrelia. In a 3D tissue‐engineered microvessel model, Borrelia extravasation across the blood–brain barrier is extremely rare, implying that neuroborreliosis is not caused via direct cytotoxicity.
Linus Wang, Zikai Xia, Anjan Singh, Bhavna Murarka, Nicole Baumgarth, John N. Aucott, Peter C. Searson   +6 more
wiley   +1 more source