Results 231 to 240 of about 55,236 (336)

Successful Therapy with Obinutuzumab in a Toddler with Primary Multidrug-Resistant Nephrotic Syndrome. [PDF]

J Clin Med
Drozynska-Duklas M, Zagozdzon I, Chudzik I, Balasz-Chmielewska I, Kranz A, Zurowska A.   +5 more
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types. [PDF]

Proc Natl Acad Sci U S A
Ahmad S, Xing K, Pereira MSF, Castle S, Rajakaruna H, Nayak I, Stewart WC, Beckwith KA, Cairo MS, Naeimi Kararoudi M, Lee DA, Das J.   +11 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

B7-H3/CD276: Novel Immune Checkpoint and Jack of All Trades. [PDF]

Immunotargets Ther
Larkin B, Nishizaki D, Miyashita H, Lee S, Nikanjam M, Eskander RN, Jensen TJ, Pabla S, Conroy JM, DePietro P, Sicklick JK, Kurzrock R, Kato S.   +12 more
europepmc   +1 more source

IMMUNOLOGICAL PROFILES OF CYTOTOXIC CELLS IS ASSOCIATED WITH TREATMENT-FREE REMISSION IN CHRONIC MYELOID LEUKEMIA

LS Binélli, LC Palma, CAB Garcia, L Marani, Márcia Melo Medeiros, AG Carvalho, PS Scheucher, Josiane Lillian Schiavinato, PMM Garibaldi, Robert S. Welner, FA Castro, KBB Pagnano, LL Figueiredo-Pontes   +12 more
openalex   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC). [PDF]

J Cancer Res Clin Oncol
Kumar RI, Jain K, Arora P, Gururajan H, Rai KR, Mukherjee O, George M, Sarkar K.   +7 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity. [PDF]

Hum Vaccin Immunother
Mendez-Gomez HR, Ligon JA, Ghiaseddin AP, Sayour EJ.   +3 more
europepmc   +1 more source