Results 281 to 290 of about 880,908 (352)

The role of Wilms' tumor gene peptide–specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone

, 2007
Kazuhiko Ikeda, Tsutomu Shichishima, Masaki Yasukawa, Akiko Nakamura‐Shichishima, Hideyoshi Noji, Kazuko Akutsu, Kazuoki Osumi, Yukio Maruyama   +7 more
openalex   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Standard: human liver-on-a-chip. [PDF]

Cell Regen
Liu H, Zhang X, Wang Y, Zhang M, Wang P, Shang J, Li Z, Gong L, Xie X, Liu D, Pi J, Gao X, Li X, Ding W, Wang D, Long Y, Wang L, Li S, Geng X, Zhou P, Tang W, Zhang X, Chen C, Yang S, Qin J.   +24 more
europepmc   +1 more source

Belantamab Mafodotin Plus Proteasome Inhibition Efficacy Versus Comparators in Early Relapsed Myeloma: A Systematic Review and Network Meta‐Analysis

American Journal of Hematology, EarlyView.
ABSTRACT In the Phase 3 DREAMM‐7 study of patients with relapsed/refractory multiple myeloma (RRMM) who received ≥ 1 prior therapy, belantamab mafodotin plus bortezomib and dexamethasone (BVd) demonstrated a progression‐free survival (PFS) benefit versus daratumumab plus bortezomib and dexamethasone (DVd).
Joshua Richter, Ajay Nooka, Paula Rodríguez‐Otero, Fredrik Schjesvold, Eirini Katodritou, Emily Combe, Marianne Scott, Leanne Cooper, Indeg Sly, Nick Ballew, Jacopo Bitetti, Natalie Boytsov, Molly Purser, Simon McNamara   +13 more
wiley   +1 more source

Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer. [PDF]

Cancer Immunol Res
Schwarz E, Savardekar H, Zelinskas S, Mouse A, Lapurga G, Lyberger J, Rivaldi A, Ringwalt EM, Miller KE, Yu L, Behbehani GK, Cripe TP, Carson WE.   +12 more
europepmc   +1 more source

Persistent Eosinophilic Inflammation Is Not a Feature of Type 2 CRS Patients Failing Anti‐IL‐5R Therapy and Requiring Class Switching to Anti‐IL‐4/13

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL‐4, ‐5, and ‐13 are prominent disease mediators. Disease control can be achieved with biologic therapies. However, despite some patients entering remission, others experience poor control. Aim We aimed to describe eCRS patients treated
Peta‐Lee Sacks, Christian M Meerwein, Peter Earls, Cedric Thiel, Christine Choy, Raewyn G Campbell, Raymond Sacks, Larry Kalish, Richard J Harvey   +8 more
wiley   +1 more source

Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis. [PDF]

J Immunol
Björk E, Israelsson P, Nagaev I, Nagaeva O, Lundin E, Ottander U, Mincheva-Nilsson L.   +6 more
europepmc   +1 more source

Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells

, 2012
Nicholas Sanderson, Mariana Puntel, Kurt M. Kroeger, Niyati Bondale, Mark Swerdlow, Niloufar Iranmanesh, Hideo Yagita∥, Ahmed Ibrahim, María G. Castro, Pedro R. Löwenstein   +9 more
openalex   +1 more source

Associations of Historic Residential Pesticide Proximity With Proinflammatory Cytokine Levels in a Patient Population With and Without Chronic Rhinosinusitis (CRS)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Residential proximity to commercial pesticide application has been associated with increased odds of developing chronic rhinosinusitis (CRS) with in vitro studies demonstrating cytotoxic dose‐dependent effects on sinonasal epithelia.
Melodyanne Y. Cheng, Kimberly C. Paul, Jakob L. Fischer, Myles G. Cockburn, Laura K. Thompson, Hong‐Ho Yang, Jeffrey D. Suh, Marilene B. Wang, Jivianne T. Lee   +8 more
wiley   +1 more source

Editorial: Immunologic tumor microenvironment modulators for turning "cold" tumors to "hot" tumors. [PDF]

Front Immunol
Ganjalıkhani-Hakemi M, Yanikkaya Demirel G, He X, Zeng C.   +3 more
europepmc   +1 more source