Results 81 to 90 of about 880,908 (352)

Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity.

Journal of Immunology, 1991
ICAM-1-mediated cell-cell adhesion is essential for various immunologic functions, including non-MHC-restricted cytotoxicity. The present study was designed to establish whether shedding of ICAM-1 from melanoma cells occurred and to characterize the ...
Jürgen C. Becker, R. Dummer, A. Hartmann, G. Burg, R. Schmidt   +4 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

NKG2D (Natural Killer Group 2, Member D) ligand expression and ameloblastoma recurrence: a retrospective immunohistological pilot study

BMC Oral Health
Background/Purpose This retrospective immunohistological pilot study aimed to investigate the influence of natural killer group 2, member D (NKG2D) ligand expression on ameloblastoma recurrence after surgical resection.
Mee-seon Kim, Soeun Jeon, Hyeon Jeong Lee, Hyun-Su Ri, Ah-Reum Cho, Eun Ji Park, Jin Song Yeo, Jae-Han Kim, Jiyoun Lee   +8 more
doaj   +1 more source

A statistical mechanics approach to autopoietic immune networks [PDF]

, 2010
The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may stem. In order to make theoretical immunology appealing to the statistical physicist audience we are going to ...
arxiv   +1 more source

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation

Journal of Clinical Investigation, 2018
DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and its ligand PD-L1 ...
F. Vendetti, P. Karukonda, D. Clump, T. Teo, R. Lalonde, Katriana Nugent, Matthew Ballew, Brian F. Kiesel, J. Beumer, Saumendra N. Sarkar, T. Conrads, M. O’Connor, R. Ferris, P. Tran, Greg M. Delgoffe, C. Bakkenist   +15 more
semanticscholar   +1 more source

Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer [PDF]

Frontiers in Immunology, 2019
Cytotoxic chemotherapeutics (CCTs) are widely used in the treatment of cancer. Although their mechanisms of action have been best understood in terms of targeting the apparatus of mitosis, an ability to stimulate anti-tumor immune responses is increasing the recognition of these agents as immunotherapies.
Opzoomer, James W., Sosnowska, Dominika, Anstee, Joanne E., Spicer, James F., Arnold, James N.   +4 more
openaire   +5 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Supplementary Data from IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma [PDF]

, 2023
Turan Aghayev, Aleksandra M. Mazitova, Jennifer R. Fang, Iuliia O. Peshkova, Matthew Rausch, Man‐Hsin Hung, Kerry White, Ricard Masia, Elizaveta K. Titerina, Aliia R. Fatkhullina, Isabelle Cousineau, Simon Turcotte, Dmitry Zhigarev, Anastasiia Marchenko, Svetlana Khoziainova, Petr Makhov, Yin Fei Tan, Andrew V. Kossenkov, David L. Wiest, John Stagg, Xin Wei Wang, Kerry S. Campbell, Amiran Dzutsev, Giorgio Trinchieri, Jonathan A. Hill, Sergei I. Grivennikov, Ekaterina K. Koltsova   +26 more
openalex   +2 more sources

"A study on Stress, Depression and NK Cytotoxic Potential in Women with Recurrent Spontaneous Abortion "

Iranian Journal of Allergy, Asthma and Immunology, 2006
It has been recognized that acute and chronic stress has an impact on the immune system. Acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated.
Alireza alib, Abass Rezaie, Farzad Oreizy, Katayoun Shafiei, Sima Baluchi   +4 more
doaj  

Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines [PDF]

arXiv, 2020
A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 + 0.31 to 438.3 3.3 {\mu}M as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 2.
arxiv