Immunology of Inflammatory Bowel Disease
Scandinavian Journal of Gastroenterology, 1985 Although the aetiology of ulcerative colitis and Crohn's disease remain unknown, immunological effector mechanisms become activated within the inflamed mucosa and may be responsible for the pathogenesis of chronic disease. There is an increased production of immunoglobulin within the mucosa, some of which has specificity for bacterial antigens, and ...
Jewell, D, Patel, C
openaire +2 more sources
Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). Methods One‐hundred‐nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and ...
Ermelinda De Meo +14 more
wiley +1 more source
Assessment of the effect of a protein calorie supplement on change in CD4 count among art-naïve female TB patients co-infected with HIV in Dar Es Salaam, Tanzania [PDF]
, 2017 RATIONALE: Tuberculosis and HIV infection together form a highly mortal combination. Even after the advent of highly active antiretroviral therapy (HAART) medications, management for Tuberculosis and HIV/AIDS still remains a challenge. Poor outcomes (in
Magohe, Albert Katana
core +1 more source
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
Immunological disturbances in myasthenia gravis with a report of Hashimoto's disease developing after thymectomy [PDF]
, 1964 J. A. Simpson
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Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia +20 more
wiley +1 more source
CD226: An Emerging Role in Immunologic Diseases. [PDF]
Front Cell Dev Biol, 2020 Huang Z, Qi G, Miller JS, Zheng SG.
europepmc +1 more source
Infectiousness in a Cohort of Brazilian Dogs: Why Culling Fails to Control Visceral Leishmaniasis in Areas of High Transmission [PDF]
, 2002 The elimination of seropositive dogs in Brazil has been used to control zoonotic visceral leishmaniasis but with little success. To elucidate the reasons for this, the infectiousness of 50 sentinel dogs exposed to natural Leishmania chagasi infection was
Courtenay, O. +4 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi +4 more
wiley +1 more source
COVID-19 and its impact on allergic and immunologic diseases in children. [PDF]
Pediatr Allergy Immunol, 2020 Eigenmann P.
europepmc +1 more source