Results 221 to 230 of about 275,636 (273)

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy

Advanced Science, EarlyView.
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu   +11 more
wiley   +1 more source

Diagnostic Inaccuracies in COPD: Misdiagnosis, Race and Gender Disparities. [PDF]

Int J Chron Obstruct Pulmon Dis
Maus SE, Norton DL, Saha AK, Wells BJ, Ohar JA.   +4 more
europepmc   +1 more source

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source

The Immunologic Downsides Associated with the Powerful Translation of Current COVID-19 Vaccine mRNA Can Be Overcome by Mucosal Vaccines. [PDF]

Vaccines (Basel)
Federico M.
europepmc   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Enhancing standardized diagnosis and treatment to improve the prognosis of patients with rheumatoid arthritis in China. [PDF]

Rheumatol Immunol Res
Jiang N, Tian X, Zeng X.
europepmc   +1 more source

Providing care for kidney transplant recipients: An overview for generalists. [PDF]

World J Nephrol
Belal AA, Santos AH, Kazory A, Koratala A.   +3 more
europepmc   +1 more source

Prediction of Lupus Classification Criteria via Generative AI Medical Record Profiling. [PDF]

BioTech (Basel)
Nair S, Lushington GH, Purushothaman M, Rubin B, Jupe E, Gattam S.   +5 more
europepmc   +1 more source

A path forward for Staphylococcus aureus vaccine development. [PDF]

J Exp Med
Fritz SA, Bubeck Wardenburg J.
europepmc   +1 more source

Integration of Longitudinal Clinical, Immunologic, and Environmental Data for Enhanced Disease Monitoring and Management in Pemphigus Vulgaris: A Case Study. [PDF]

JID Innov
Baroukhian J, Seiffert-Sinha K, Sinha AA.   +2 more
europepmc   +1 more source