Results 51 to 60 of about 7,547,939 (303)

Update on the treatment navigation for functional cure of chronic hepatitis B: Expert consensus 2.0 [PDF]

Clinical and Molecular Hepatology
As new evidence emerges, treatment strategies toward the functional cure of chronic hepatitis B are evolving. In 2019, a panel of national hepatologists published a Consensus Statement on the functional cure of chronic hepatitis B.
Di Wu, Jia-Horng Kao, Teerha Piratvisuth, Xiaojing Wang, Patrick T.F. Kennedy, Motoyuki Otsuka, Sang Hoon Ahn, Yasuhito Tanaka, Guiqiang Wang, Zhenghong Yuan, Wenhui Li, Young-Suk Lim, Junqi Niu, Fengmin Lu, Wenhong Zhang, Zhiliang Gao, Apichat Kaewdech, Meifang Han, Weiming Yan, Hong Ren, Peng Hu, Sainan Shu, Paul Yien Kwo, Fu-sheng Wang, Man-Fung Yuen, Qin Ning   +25 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis [PDF]

, 2016
Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of the atopic diathesis. Recent evidence supports the concept that AD can also recognize other comorbidities, such as chronic inflammatory bowel or cardiovascular ...
Werfel, T., Guttman-Yassky, E., Werfel, Thomas, Hoetzenecker, W., Bieber, Thomas, Knol, E., Wollenberg, Andreas, Schmid-Grendelmeier, Peter, Biedermann, Tilo, Gilles, Stefanie, Akdis, Cezmi A, Gilles, S., Akdis, Cezmi A., Guttman-Yassky, Emma, Bieber, T., Hoetzenecker, Wolfram, Wollenberg, A., Simon, H.U., Allam, Jean-Pierre, Allam, J.P., Lauener, R., Traidl-Hoffmann, C., Eyerich, K., Biedermann, T., Lauener, Roger, Traidl-Hoffmann, Claudia, Akdis, C.A., Simon, Hans-Uwe, Knol, Edward, Schmid-Grendelmeier, P., Eyerich, Kilian   +30 more
core   +3 more sources

Eculizumab, a successful treatment for atypical postpartum hemolytic-uremic syndrome: a case report

Revista Chilena de Obstetricia y Ginecología, 2022
Atypical hemolytic-uremic syndrome (aHUS) is a rare entity characterized by the association of acute kidney failure, thrombocytopenia and microangiopathic hemolytic anemia due to the dysregulation of the alternative pathway of the complement system.
Isabel Eznarriaga-Pérez, Pedro M. Tabernero-Rico   +1 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Evaluation of Lipocalin-2 Levels in Gingival Crevicular Fluid and Serum of Periodontitis Patients: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Periodontitis is a chronic inflammatory disease affecting the supporting structures of teeth, and directly challenges the immune response, presented in elevation of many inflammatory mediators and cytokines.
Ehab Azab, Amal S Alqahtani, Ghaida Alshareef, Huriyyah Alotaibi, Alaa Moustafa, Abdel-Rahman Youssef   +5 more
doaj   +1 more source

Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention

Pathogens and Immunity, 2023
Coronavirus disease 2019 (COVID-19) has had profound effects on the health of individuals and on healthcare systems worldwide. While healthcare workers on the frontlines have fought to quell multiple waves of infection, the efforts of the larger ...
David Sweet, Michael Freeman, David Zidar   +2 more
doaj   +1 more source

Immunologic Factors in the Recurrence of Glioma

Neurologia medico-chirurgica, 1988
Glioma often recurs after apparently successful treatment and clinical remission. The effect of the host's immunologic status in such cases is unknown. In this study, the authors attempted to answer the following questions: 1) Is there a relationship between immunity and the recurrence of glioma?
OGASHIWA, Motohide, ASOH, Yuji, MAEDA, Tatsuhiro, YOKOYAMA, Haruhisa, TAKEUCHI, Kazuo   +4 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source