Results 61 to 70 of about 133,571 (308)

Association between HIV genotype, viral load and disease progression in a cohort of Thai men who have sex with men with estimated dates of HIV infection. [PDF]

PLoS ONE, 2018
BACKGROUND:Differences between HIV genotypes may affect HIV disease progression. We examined infecting HIV genotypes and their association with disease progression in a cohort of men who have sex with men with incident HIV infection in Bangkok, Thailand.
Wanna Leelawiwat, Sarika Pattanasin, Anuwat Sriporn, Punneeporn Wasinrapee, Oranuch Kongpechsatit, Famui Mueanpai, Jaray Tongtoyai, Timothy H Holtz, Marcel E Curlin   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Does endometriosis increase susceptibility to COVID-19 infections? A case–control study in women of reproductive age

BMC Women's Health, 2021
Background In today’s world, coronavirus disease 2019 (COVID-19) is the most critical health problem and research is continued on studying the associated factors. But it is not clear whether endometriosis increases the risk of COVID-19. Methods Women who
Bahram Moazzami, Shahla Chaichian, Saeed Samie, Masoumeh Majidi Zolbin, Fatemeh Jesmi, Meisam Akhlaghdoust, Mahin Ahmadi Pishkuhi, Zahra Sadat Mirshafiei, Fereshteh Khalilzadeh, Dorsa Safari   +9 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Cytogenetic, Inflammatory, Immunologic, and Infectious Basis for Dysplastic Hematopoeisis

, 2017
Myelodysplastic syndrome is a heterogeneous immunologic and epigenetic group of myeloid disorders with variable propensity for acute myelogenous leukemia (AML) conversion. Treatment is limited to growth factors, lenalidomide for 5q deletion MDS, and best
Gustavo Rivero, Pedro Alcedo, null null, Enrique Andrade, Hussein Hamad   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Chronic renal allograft rejection: Immunologic and nonimmunologic risk factors

, 1996
Chronic renal allograft rejection: Immunologic and nonimmunologic risk factors. The pathogenesis of chronic renal allograft rejection is unknown. It is also unclear why cyclosporine has failed to prevent chronic rejection.
Massy, Ziad A., Guijarro, Carlos, Ma, Jennie Z., Wiederkehr, Michael R., Kasiske, Bertram L.   +4 more
core   +1 more source

Chicken consumption and use of acid-suppressing medications as risk factors for Campylobacter enteritis, England. [PDF]

, 2009
In a case-control study of Campylobacter spp. risk factors in England during 2005-2006, we identified recent consumption of commercially prepared chicken as an important risk factor.
Higgins, Craig D, Rodrigues, L.C, Neal, Keith R, Tam, Clarence C., Neal, K.R, Laura C. Rodrigues, Sally E. Millership, Craig D. Higgins, O'Brien, Sarah J, O'Brien, Sarah J., Higgins, C.D, O'Brien, S.J, Neal, Keith R., Tam, Clarence C, Millership, S.E, Clarence C. Tam, Keith R. Neal, Higgins, Craig D., Sarah J. O’Brien, Campylobacter Case-Control Study Group, Rodrigues, Laura C., Millership, Sally E., Rodrigues, Laura C, Millership, Sally E, Tam, C.C   +24 more
core   +1 more source

Immunologic Factors in the Recurrence of Glioma

Neurologia medico-chirurgica, 1988
Glioma often recurs after apparently successful treatment and clinical remission. The effect of the host's immunologic status in such cases is unknown. In this study, the authors attempted to answer the following questions: 1) Is there a relationship between immunity and the recurrence of glioma?
OGASHIWA, Motohide, ASOH, Yuji, MAEDA, Tatsuhiro, YOKOYAMA, Haruhisa, TAKEUCHI, Kazuo   +4 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source