Results 121 to 130 of about 1,924,532 (299)

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Clinton League members looking at Memory Book

, 1946
Photograph showing charter members of the Clinton League looking at group's "Memory Book" covering the years 1912-1938. The women are identified as Mrs. Pierson, Mrs. Cottrell and Mrs. H.C. Marshall. This image was included in a "Memory Book" compiled by

core  

Recollection reduces unitised familiarity effect

, 2015
Two types of encoding tasks have been employed in previous research to investigate the beneficial effect of unitisation on familiarity-based associative recognition (unitised familiarity effect), namely the compound task and the interactive imagery task.
Shao, Hanyu, Shao, H, Yang, Jiongjiong, Weng, Xuchu, Weng, X, Opitz, Bertram, Yang, J, Opitz, B   +7 more
core   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

An introduction to immunology and immunopathology

Allergy, Asthma & Clinical Immunology, 2018
Beyond structural and chemical barriers to pathogens, the immune system has two fundamental lines of defense: innate immunity and adaptive immunity. Innate immunity is the first immunological mechanism for fighting against an intruding pathogen.
Jean S. Marshall, Richard Warrington, Wade Watson, Harold L. Kim   +3 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanuspertussis vaccine in atopic versus nonatopic children

, 2000
Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanuspertussis vaccine in atopic versus nonatopic ...
C Macaubas (13368867), PG Holt (14457411), BJ Holt (14457651), A Rudin (9281921), PD Sly (14453628), J Rowe (9877307), R Loh (13369182)   +6 more
core  

Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants

, 2011
Genetic studies in Drosophila have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM).
Guan, Zhuo, Quinn, William G., William G. Quinn, Zhuo Guan, Buhl, Lauren Kaye, Littleton, J. Troy, J. Troy Littleton, Lauren K. Buhl   +7 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source