Results 161 to 170 of about 43,875 (259)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Immune checkpoint landscape in CD4⁺ T cells stratifies HIV-infected individuals by clinical progression. [PDF]

Immunol Res
Spampinato S, Scuderi G, Di Rosa M, Fagone P, Nunnari G.   +4 more
europepmc   +1 more source

Long-term T-cell-mediated immunologic memory to hepatitis B vaccine in young adults following neonatal vaccination. [PDF]

Hepat Mon, 2014
Saffar H, Saffar MJ, Ajami A, Khalilian AR, Shams-Esfandabad K, Mirabi AM.   +5 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Comprehensive assessment of allergic manifestations including drug hypersensitivity in adult patients with inborn errors of immunity. [PDF]

Allergy Asthma Proc
Korkmaz P, Toprak ID, Demir S, Yegit OO, Kahveci N, Hormet Igde M, Celik Kamaci S, Aslan AF, Atasever MD, Eyice Karabacak D, Sezgin ME, Guzel SE, Kaya E, Erden B, Kilinc Z, Imren Aksit IG, Bolek L, Unal D, Gelincik A.   +18 more
europepmc   +1 more source

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor Responses. [PDF]

Cancer Immunol Res
Sidiropoulos DN, Zhang Z, Durham JN, Charmsaz S, Gross NE, Lee JW, Sun Y, Perikala S, Tandurella JA, Lvovs D, Mitschang A, Lemson G, Shin SM, Hernandez AG, Mitchell S, Leatherman JM, Danilova L, Wang H, Fertig EJ, Jaffee EM, Bever KM, Le DT, Ho WJ.   +22 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Flipping the script: Using mucosal immune obstacles to inform vaccine design. [PDF]

PLoS Pathog
Antia A, Ding S.
europepmc   +1 more source

Paradoxical inflammatory switches during biologic therapy: a mechanistic framework, clinical algorithm, and pediatric illustrations. [PDF]

Front Pediatr
Kowacka M, Dec M, Arasiewicz H.
europepmc   +1 more source