Results 41 to 50 of about 51,877 (297)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Contact-allergy time [PDF]

, 1986
The most commonly used techniques for the in vivo evaluation of the cellular immune response include intracutaneous testing with microbial recall antigens or sensitization with neoantigens.
Bogner, Johannes R., Ring, J., Burg, G., Przybilla, B.   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Laparoscopic splenectomy advantages over open surgery [PDF]

Reviews in Clinical Medicine, 2015
In recent years, laparoscopy has become a popular surgical method. Laparoscopy is a minimally invasive surgery, which results in minor traumas in comparison with conventional open surgeries.
Majid Safarpanah, Mehran Hiradfar
doaj   +1 more source

DNA yield and quality of saliva samples and suitability for large scale epidemiological studies in children [PDF]

, 2011
Objective: To evaluate two saliva collection methods for DNA yield and quality as applied to a large, integrated, multicentre, European project involving the collection of biological material from children.
Bailey, Mark E.S., Koni, Anna C., Y P Pitsiladis, J Peplies, Scott, Robert A., G Wang, Wang, G., Bailey, M.E.S., K Bammann, Wang, Guan; id_orcid, Scott, R.A., Peplies, J., Pitsiladis, Y.P., R A Scott, A C Koni, null null, Bammann, K., Pitsiladis, Yannis; id_orcid, Koni, A.C., M E S Bailey   +19 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model

Plastic and Reconstructive Surgery, Global Open
Background:. Representative translational animal models play a key role in vascularized composite allotransplantation (VCA) research. A composite porcine hindlimb flap, previously described, is a relevant preclinical model. However, its bulkiness and the
Stefanie Hirsiger, MD, Ioana Lese, MD, Isabel Arenas Hoyos, MD, Cédric Zubler, MD, David Haberthür, PhD, Ruslan Hlushchuk, MD, Valentin Djonov, MD, Yara Banz, MD, PhD, Ana Macek, MD, Hendrik von Tengg-Kobligk, MD, Daniela Casoni, VMD, PhD, Robert Rieben, PhD, Radu Olariu, MD, PhD   +12 more
doaj   +1 more source

Biomaterial selection for bone augmentation in implant dentistry: A systematic review

Journal of Advanced Pharmaceutical Technology & Research, 2019
In the present study, a systematic review was conducted to evaluate the biomaterials and their effectiveness for bone augmentation in implant dentistry.
Erfan Shamsoddin, Behzad Houshmand, Mehdi Golabgiran   +2 more
doaj   +1 more source

Surgical techniques for pancreas transplantation

, 2005
Purpose of review: From the beginning, pancreas transplantation proved to be effective but was associated with high rates of surgical complications and technical failure. Duct management and venous drainage were soon identified as major issues.
MARCHETTI, PIERO, Mosca F., BOGGI, UGO, Coppolli A, Del Chiaro M, VISTOLI, FABIO, DI CANDIO, GIULIO, Amorese G, Signori S   +8 more
core   +1 more source