Results 171 to 180 of about 26,657 (231)

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Evaluating the Immunological Impact of Hepatitis B Vaccination in Patients with Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Soleto I, Marin AC, Baldan-Martin M, Bernardo D, Chaparro M, Gisbert JP.   +5 more
europepmc   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Mechanistic insights into FMT for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial. [PDF]

J Crohns Colitis
Quraishi MN, Moakes CA, Yalchin M, Blackwell C, Segal J, Ives NJ, Magill L, Manzoor SE, Gerasimidis K, McMullan C, Mathers J, Horniblow R, Loi S, Kaur M, Loman NJ, Sharma N, Hawkey P, McCune V, Quick J, Nicholls S, McMurray C, Nichols B, Svolos V, Raguideau S, Kerbiriou C, Oo YH, Beggs AD, Crees N, Hansen R, Hart AL, Gaya DR, Quince C, Iqbal TH.   +32 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire. [PDF]

ESMO Open
Zierfuss C, Niederdorfer B, Fendl B, Syböck K, Schedl J, Kohl L, Heller G, Tomasich E, Berger JM, Sunder-Plassmann V, Kleinberger M, Gottmann L, Korpan M, Starzer AM, Solano Henao I, Fürst J, Wolfsberg J, Grohmannova M, Dobrovits N, Ay C, Vladic N, Furtner J, Preusser M, Berghoff AS.   +23 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Defining and Predicting HIV Immunological Non-Response: A Multi-Definition Analysis from an Indonesian Cohort. [PDF]

Viruses
Rachman BE, Supranoto YTN, Iskandar SI, Asmarawati TP, Khairunisa SQ, Arfijanto MV, Hadi U, Miftahussurur M, Nasronudin N, Kameoka M, Rahayu RP, Hidayati AN.   +11 more
europepmc   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Baseline tumor features and systemic immune dynamics underlying efficacy in MSS metastatic colorectal cancer treated with regorafenib, ipilimumab, and nivolumab. [PDF]

Cancer Immunol Res
Ye J, Wang C, Egelston CA, Guo W, Mannan R, Lee PP, Fakih MG.   +6 more
europepmc   +1 more source