Results 91 to 100 of about 1,301,152 (340)

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

open access: yes, 2020
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P.   +6 more
core   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

open access: yesFEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran   +3 more
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

FUNDAMENTAL STUDIES IN BASIC AND CLINICAL IMMUNOLOGY PERFORMED BY ACADEMICIAN V.I. IOFFE (TO THE 120th ANNIVERSARY OF THE BIRTH OF ACADEMICIAN V.I. IOFFE)

open access: yesМедицинская иммунология, 2018
In 2018, we celebrate the 120th anniversary of Academician, Professor Vladimir I Ioffe, a leading figure of national immunology. The world-level achievements of V.I.Ioffe in research, his undisputed priority in the most important areas of fundamental ...
P. G. Nazarov, I. S. Freydlin
doaj   +1 more source

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