The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
Corrigendum to "Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection" [Mucosal. Immun. 17 (2024) 1242-1255]. [PDF]
Chawla AS+17 more
europepmc +1 more source
Transplantation Immunology of the Anterior Chamber of the Eye [PDF]
Henry J. Kaplan+2 more
openalex +1 more source
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali+5 more
wiley +1 more source
Erratum: Data standards for single-cell RNA-sequencing of paediatric cancer. [PDF]
europepmc +1 more source
Editorial: Immune correlates of protection: Insight into microbial co-infection with special emphasis on influenza-<i>Streptococcus pneumoniae</i> superinfection. [PDF]
Barman TK, Dutta A, Stout-Delgado HW.
europepmc +1 more source
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams+7 more
wiley +1 more source
Corrigendum to "Impaired Proliferation of CD8<sup>+</sup> T Cells Stimulated with Monocyte-Derived Dendritic Cells Previously Matured with Thapsigargin-Stimulated LAD2 Human Mast Cells". [PDF]
europepmc +1 more source
Asymptomatic hypertension and bilateral renal artery stenosis in Takayasu arteritis. [PDF]
Tsai WH, Cheng CF.
europepmc +1 more source