Results 111 to 120 of about 5,981,210 (344)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection

JCI Insight
BACKGROUND T cell responses are impaired in Staphylococcus aureus–infected children, highlighting a potential mechanism of immune evasion. This study tested the hypotheses that toxin-specific antibodies protect immune cells from bacterial killing and are
Maureen Kleinhenz, Zhaotao Li, Usha Chidella, Walissa Picard, Amber Wolfe, Jill Popelka, Robin Alexander, Christopher P. Montgomery   +7 more
doaj   +1 more source

CAR Immunotherapy for the treatment of infectious diseases: a systematic review

Frontiers in Immunology
Immunotherapy treatments aim to modulate the host’s immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer.
E. Morte-Romea, C. Pesini, Galadriel Pellejero-Sagastizabal, Santiago Letona-Giménez, Luis Martínez-Lostao, S. Aranda, Carla Toyas, Sergio Redrado, Elena Dolader-Ballesteros, Maykel A. Arias, Eva M. Gálvez, Rebeca Sanz-Pamplona, Julian Pardo, J. Paño-Pardo, Ariel Ramírez-Labrada   +14 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterisation of strains of enteroaggregative Escherichia coli isolated during the infectious intestinal disease study in England. [PDF]

, 2001
Strains of Escherichia coli, hybridising with a DNA probe for enteroaggregative E. coli (EAggEC), were isolated from patients with infectious intestinal disease (IID) or gastro-enteritis, and healthy controls during the study of IID in England.
Wheeler, JG, Evans, J, Cheasty, T, Tompkins, D, Chart, H, Wilson, A, Smith, HR   +6 more
core   +1 more source

Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humans

JCI Insight
To unravel the heterogeneity and molecular signature of effector memory Th2 cells (Tem2), we analyzed 23 individuals’ PBMCs of filaria-infected (Filaria+) and 24 healthy volunteers (Filaria–), with or without coincident house dust mite (HDM) allergic ...
Pedro H. Gazzinelli-Guimaraes, Brittany Dulek, Phillip Swanson, Justin Lack, Mario Roederer, Thomas B. Nutman   +5 more
doaj   +1 more source

Immunological aspects of infectious diseases

Kazan medical journal, 1984
The modern understanding of infectology is not limited to acute mass infections only. Currently, the importance of opportunistic bacteria is increasingly increasing; especially in the occurrence of nosocomial outbreaks of infections. They are often the cause of deaths in patients in surgical, hematology, intensive care and other departments, as well as
openaire   +1 more source

Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease

Annual Review of Immunology, 2014
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular Apicomplexa family, the most deadly of which, Plasmodium falciparum, prevails in Africa. Malaria imposes a huge health burden on the world’s most vulnerable populations,
P. Crompton, Jacqueline Moebius, S. Portugal, M. Waisberg, G. Hart, Lindsey S. Garver, L. Miller, C. Barillas, S. Pierce   +8 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intraepithelial CD15 infiltration identifies high-grade anal dysplasia in people with HIV

JCI Insight
Men who have sex with men (MSM) with HIV are at high risk for squamous intraepithelial lesion (SIL) and anal cancer. Identifying local immunological mechanisms involved in the development of anal dysplasia could aid treatment and diagnostics.
Joaquín Burgos, Aleix Benítez-Martínez, Cristina Mancebo, Núria Massana, Antonio Astorga-Gamaza, Josep Castellvi, Stefania Landolfi, Adrià Curran, Jorge N. Garcia-Perez, Vicenç Falcó, María J. Buzón, Meritxell Genescà   +11 more
doaj   +1 more source