Results 101 to 110 of about 5,981,210 (344)
Endothelial GSDMD underlies LPS-induced systemic vascular injury and lethality
JCI InsightEndothelial injury destroys endothelial barrier integrity, triggering organ dysfunction and ultimately resulting in sepsis-related death. Considerable attention has been focused on identifying effective targets for inhibiting damage to endothelial cells ...
Enyong Su +7 more
doaj +1 more source
The Journal of Clinical Investigation, 2023 T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses ...
Satomi Ando +11 more
doaj +1 more source
Furin‐mediated protein processing in infectious diseases and cancer
Clinical & Translational Immunology, 2019 Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, D. Sauter
semanticscholar +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection
JCI InsightUrinary neutrophils are a hallmark of urinary tract infection (UTI), yet the mechanisms governing their activation, function, and efficacy in controlling infection remain incompletely understood.
Vicki Mercado-Evans +9 more
doaj +1 more source
JCI Insight, 2021 As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or
Carolina Garrido +18 more
doaj +1 more source
Immunological barrier for infectious diseases [PDF]
Applicationes Mathematicae, 1997 Summary: A nonlinear mathematical model with distributed delay is proposed to describe the reaction of a human organism to a pathogen agent. The stability of the disease free state is analyzed, showing that there exists a large set of initial conditions in the attraction basin of the disease-free state whose border is defined as the immunological ...
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B [PDF]
, 2006 Infectious bursa] disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease.
Lam, PY +19 more
core +1 more source
BTK drives neutrophil activation for sterilizing antifungal immunity
The Journal of Clinical InvestigationWe describe a previously unappreciated role for Bruton’s tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B cell lymphoid malignancies.
Jigar V. Desai +27 more
doaj +1 more source