Results 51 to 60 of about 5,981,210 (344)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Systematic analysis of funding awarded to institutions in the United Kingdom for infectious disease research, 1997-2010. [PDF]

, 2015
OBJECTIVES: This study aimed to assess the research investments made to UK institutions for all infectious disease research and identify the direction of spend by institution. DESIGN: Systematic analysis.
Atun, Rifat, Head, M., Fitchett, Joseph R, Moore, David Aj, Atun, R., Moore, DA, Atun, R, Moore, D.A., Head, MG, Fitchett, JR, Fitchett, J.R., Head, Michael G   +11 more
core   +1 more source

NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice

JCI Insight, 2022
Immune cells express an array of inhibitory checkpoint receptors that are upregulated upon activation and limit tissue damage associated with excessive response to pathogens or allergens.
Ha-Na Lee, Mohanraj Manangeeswaran, Aaron P. Lewkowicz, Kaliroi Engel, Monica Chowdhury, Mamatha Garige, Michael A. Eckhaus, Carole Sourbier, Derek D.C. Ireland, Daniela Verthelyi   +9 more
doaj   +1 more source

Pearls collections: What we can learn about infectious disease and cancer

PLoS Pathogens, 2018
1 Department of Medical Microbiology and Immunology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, 2 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States
L. Knoll, D. A. Hogan, J. Leong, J. Heitman, R. Condit   +4 more
semanticscholar   +1 more source

Bovine Immunology: Implications for Dairy Cattle

Frontiers in Immunology, 2021
The growing world population (7.8 billion) exerts an increased pressure on the cattle industry amongst others. Intensification and expansion of milk and beef production inevitably leads to increased risk of infectious disease spread and exacerbation ...
A. Vlasova, L. Saif
semanticscholar   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

A two-component model for counts of infectious diseases [PDF]

, 2005
We propose a stochastic model for the analysis of time series of disease counts as collected in typical surveillance systems on notifiable infectious diseases.
Schmid, V, Held, Leonhard, Höhle, Michael, Held, L, Hofmann, M., Hofmann, Mathias, Höhle, M, Schmid, Volker J., Schmid, Volker, Hofmann, M   +9 more
core   +1 more source

Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice

JCI Insight, 2022
Cellular and molecular mechanisms driving morbidity following SARS-CoV-2 infection have not been well defined. The receptor for advanced glycation end products (RAGE) is a central mediator of tissue injury and contributes to SARS-CoV-2 disease ...
Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M. Roberts, Eric Bohrnsen, John R. Hoidal, Catharine M. Bosio   +6 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Multinational corporations and infectious disease : embracing human rights management techniques [PDF]

, 2015
Global health institutions have called for governments, international organisations and health practitioners to employ a human rights-based approach to infectious diseases.
Wielga, Mark, Utzinger, Jürg, Salcito, Kendyl, Singer, Burton H., Winkler, Mirko S., Krieger, Gary R., Weiss, Mitchell G.   +6 more
core   +1 more source