Results 171 to 180 of about 254,342 (304)

Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia

American Journal of Hematology, EarlyView.
ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Melissa A. Fischer, Zhiguo Zhao, Kateryna Fedorov, Ashwin Kishtagari, Sanjay R. Mohan, Gregory D. Ayers, Michael T. Byrne, Michael R. Savona   +11 more
wiley   +1 more source

Validity of PEN-FAST as a clinical decision tool in pregnant patients. [PDF]

J Allergy Clin Immunol Glob
You L, Belmont AP, Liao J, Su C, Trubiano JA, Son M, Burn MS, Kwah J.   +7 more
europepmc   +1 more source

Real‐World Effectiveness and Safety of Ravulizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria: Evidence From the International PNH Registry

American Journal of Hematology, EarlyView.
ABSTRACT Ravulizumab, a second‐generation complement component 5 inhibitor (C5i) derived from eculizumab, with improved pharmacokinetics, is the current standard‐of‐care treatment for patients with paroxysmal nocturnal hemoglobinuria (PNH), where available.
Alexander Röth, Christopher J. Patriquin, Jeff Szer, Louis Terriou, Ami S. Patel, Jesse Metzger, Philippe Gustovic, Jun‐ichi Nishimura, Robert A. Brodsky   +8 more
wiley   +1 more source

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis. [PDF]

JAMA Pediatr
Islam N, Chu AWL, Sheriff F, Foroutan F, Guyatt GH, Brignardello-Petersen R, Oykhman P, Iorio A, Izcovich A, Morrison KM, Roldan Benitez Y, Couban RJ, Borovsky D, Zhang Y, Ologundudu L, Pasumarthi K, Farooq SF, Tong K, Tang WC, Faisal H, Khalid MF, Asif MS, French S, Waserman S, Chinthrajah RS, Sampson HA, Mustafa SS, Lieberman JA, Järvinen KM, Bailey S, Bégin P, Sicherer SH, Gerdts J, Carver M, Mitchell L, Cleary K, Greenhawt MJ, Wang J, Anagnostou A, Shaker MS, Chandra-Puri A, Fulkerson PC, Wood RA, Chu DK.   +43 more
europepmc   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, EarlyView.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Artificial Intelligence Exhibits Critical Blind Spots in Allergy Test Room Safety Design. [PDF]

Healthc Inform Res
Dumanoglu B, Sahin C, Bostan OC, Koksal ZG, Cerci P.   +4 more
europepmc   +1 more source

Epidemiology of Cancer‐Associated Venous Thromboembolism Across the United States

American Journal of Hematology, EarlyView.
ABSTRACT Prior epidemiological studies on cancer‐associated venous thromboembolism (VTE) were limited by homogenous patient populations. We leverage Cosmos, a collaborative dataset of Epic electronic health record systems, to conduct an updated evaluation of cancer‐associated VTE in the United States (US).
Barbara D. Lam, Justine Ryu, Omid Jafari, Rock Bum Kim, Shengling Ma, Mrinal Ranjan, Jun Y. Jiang, Ang Li   +7 more
wiley   +1 more source

FoodCHOMP (Food Challenge-at HOme or in Medical Practice): a pilot multicentre randomised controlled trial evaluating home versus clinic-based food allergy challenges in low-risk adults-study protocol. [PDF]

BMJ Open
Godsell J, Vogrin S, Chan S, Henri M, Ng I, Andrews E, Spriggs K, Perrett KP, Trubiano J.   +8 more
europepmc   +1 more source

Knowledge about occupational latex allergy amongst Thai nurses and student nurses. [PDF]

, 2011
De Vocht, Frank, Povey, Andrew, Supapvanich, Chompunuch   +2 more
core   +1 more source

Late Onset Telomere Biology Disorder Presenting With Pancytopenia, Immune Dysregulation, Interstitial Lung Disease and Alopecia

American Journal of Hematology, EarlyView.
Bo A. Wan, Hamish Nicolson, Heather A. Leitch, Ryan J. Stubbins, Luke Y. C. Chen, Timothy Murray, Amy Trottier, Anthony Gador   +7 more
wiley   +1 more source