Results 231 to 240 of about 263,557 (352)
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy, Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu +16 morewiley +1 more sourceExtracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen +5 morewiley +1 more sourceNotch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis
Advanced Science, EarlyView.Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen +10 morewiley +1 more sourceRapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework
Advanced Science, EarlyView.In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau +14 morewiley +1 more sourceMethodology for the Development of the Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI 2024-2025 Guidelines: From Evidence-to-Decision Frameworks to Digitalised Shared Decision-Making Algorithms. [PDF]
AllergyBousquet J, Sousa-Pinto B, Vieira RJ, Schünemann HJ, Zuberbier T, Bognanni A, Togias A, Samolinski B, Valiulis A, Williams S, Bedbrook A, Czarlewski W, Torres MJ, Shamji MH, Morais-Almeida M, Canonica GW, Vecillas LL, Dykewicz MS, Jacomelli C, Klimek L, Leemann L, Lourenço O, Palamarchuk Y, Papadopoulos NG, Pereira AM, Savouré M, Toppila-Salmi SK, Ventura MT, Yepes-Nuñez JJ, Cruz AA, Ciprandi G, Gemicioglu B, Giovannini M, Gradauskiene B, Jartti T, Jeseňák M, Kuna P, Kvedariene V, Larenas-Linnemann DE, Latiff AHA, Mohammad Y, Ohta K, Mahesh PA, Pali-Schöll I, Pfaar O, Regateiro FS, Roche N, Sofiev M, Taborda-Barata L, Ulrik CS, Rostan MV, Viegi G, Zhang L, Antó JM, Haahtela T, Cherrez-Ojeda I, Ivancevich JC, Khaltaev N, Yorgancioglu A, Abdullah B, Al-Ahmad M, Al-Nesf MA, Amaral R, Asllani J, Bergmann KC, Bernstein JA, Blaiss MS, Braido F, Camargos P, Carreiro-Martins P, Casale T, Cecchi L, Fiocchi AG, Giuliano AFM, Christoff G, Cirule I, Correia-de-Sousa J, Costa EM, Del Giacco S, Devillier P, Dokic D, Hossny E, Iinuma T, Irani C, Ispayeva Z, Julge K, Kaidashev I, Bennoor KS, Kraxner H, Kull I, Kulus M, Kupczyk M, Kurchenko A, La Grutta S, Miculinic N, Tuyet LLT, Makris M, Milenkovic B, Lee SM, Montefort S, Moreira A, Mullol J, Nadif R, Nakonechna A, Neffen HE, Niedoszytko M, Nyembue D, O'Hehir R, Ogulur I, Okamoto Y, Olze H, Palomares O, Panzner P, Patella V, Pawankar R, Pitsios C, Popov TA, Puggioni F, Quirce S, Ramonaité A, Recto M, Repka-Ramirez MS, Roberts G, Robles-Velasco K, Rottem M, Salapatas M, Sastre J, Scichilone N, Sisul JC, Solé D, Soto-Martinez ME, Sova M, Tantilipikorn P, Todo-Bom A, Tsaryk V, Tsiligianni I, Urrutia-Pereira M, Valovirta E, Van Ganse E, Vasankari T, Wallace D, Wang Y, Worm M, Yusuf OM, Zidarn M, Gil-Mata S, Marques-Cruz M, Mahboub B, Ansotegui IJ, Romano A, Artesani MC, Barreto B, Becker S, Beghe B, Bouchard J, Bourgoin-Heck M, Brussino L, Buhl R, Calvo-Gil M, Dahl VC, Vizuete JAC, Charpin D, Chavannes NH, Chełmińska M, Cheng L, Chkhartishvili E, Chong-Neto HJ, Choudhury D, Chu D, Cingi C, Compalati E, Cvetkovski B, Da Silva J, D'Amato G, Davies J, Di Bona D, Dimou MV, Teixeira MDC, Doulaptsi M, Pérez JMF, Gawlik R, Goksel O, Gómez MR, Gonzalez Diaz SN, Gotua M, Grigoreas C, Grisle I, Guzman MA, Tan RH, Hyland M, Ierodiakonou D, Karavelia A, Kisiel M, Kosnik M, Kritikos V, Lombardi C, Martini M, Meço C, Mesonjesi E, Mihaltan F, Moniuszko M, Naclerio R, Neisinger S, Ordak M, Paoletti G, Perdomo-Flores EA, Pham-Thi N, Prokopakis E, Yeverino DR, Rolla G, Romantowski J, Rouadi PW, Rukhadze M, Sakurai D, Salameh L, Sarquis FS, Kosak TS, Soyka M, Sozinova O, Specjalski K, Tomic-Spiric V, Vachova M, van Hage M, Koyuncu IV, Vichyanond P, Wagenmann M, Ko FWS, Werminghaus P, Xepapadaki VP, Xiang YK, Fonseca JA. +230 moreeuropepmc +1 more sourceA Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4
Advanced Science, EarlyView.This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong +11 morewiley +1 more source
