Results 101 to 110 of about 142,022 (295)

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

Frontiers in Immunology, 2019
Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the
Hyang Ju Lee, Hyang Ju Lee, Bongkun Choi, Bongkun Choi, Yongsub Kim, Yongsub Kim, Sang Eun Lee, Sang Eun Lee, Hye Jin Jin, Hee-Seop Lee, Hee-Seop Lee, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang, Seong Who Kim, Seong Who Kim   +15 more
doaj   +1 more source

Immunomodulation under the lens of real‐time in vivo imaging [PDF]

, 2023
Philippe Bousso, Capucine L. Grandjean
openalex   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Mechanism of action of probiotics [PDF]

, 2013
The modern diet doesn't provide the required amount of beneficial bacteria. Maintenance of a proper microbial ecology in the host is the main criteria to be met for a healthy growth.
Balcazar JL, Caglar E, Connolly E, Cremonini F, De Keersmaecker SC, Delcenserie V, Eizaguirre I, Fioramonti Jean, Fonden R, Galdeano CM, Guarner F, Hallegraeff GA, Harish K, Haskard CA, Imase K, Irianto A, Isabel S. Carvalho, Kaila M, Kaila M, Katharina E, Link-Amster H, Lionetti E, Mangell P, Marteau P, Mattar AF, Michael de Vrese, Norin E, Oatley JT, R. Raja, R. Ravikumar, Raja R, Raja R, Raja R, Raja R, Reid G, S Hemaiswarya, Saggioro A, Salminen S, Sarah Lebeer, Silva M, Singh SD, Tubelius P, Venkat HK, Vrese M, Weber P, Wolf BW   +45 more
core   +4 more sources

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, EarlyView.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Main lesions in the central nervous system of dogs due to Leishmania infantum infection

BMC Veterinary Research, 2017
Background Canine visceral leishmaniasis (CVL) is endemic in São Luís Maranhão/Brazil and it leads a varied clinical picture, including neurological signs.
Weline Lopes Macau, Joicy Cortez de Sá, Ana Patrícia de Carvalho da Silva, Alessandra Lima Rocha, Renata Mondêgo-Oliveira, Fábio Henrique Evangelista de Andrade, Caroline Magalhães Cunha, Kátia da Silva Calabrese, Ana Lucia Abreu-Silva   +8 more
doaj   +1 more source

Cell-Mediated Immunoreactivity of Poly(2-isopropenyl-2-oxazoline) as Promising Formulation for Immunomodulation [PDF]

, 2021
Ema Paulovičová, Zuzana Kroneková, Lucia Paulovičová, Monika Majerčíková, Juraj Kronek   +4 more
openalex   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source