Results 131 to 140 of about 203,110 (265)

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Enzyme-Assisted Extraction of Polysaccharides from Steam-Exploded <i>Ganoderma lucidum</i> and Its Yield, Structural Characterisation, and Immunomodulatory Activity. [PDF]

Molecules
Liu J, Yang Z, Huang J, Sun C, Chen L, Zhu Z.   +5 more
europepmc   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Selenium-induced structural reorganization of polysaccharides from blackened jujube pomace enhances immunomodulatory activity. [PDF]

Front Nutr
Zhao M, Sun X, Wang Y, Gao L, Zhang R.
europepmc   +1 more source

Immunomodulatory Activity and Its Mechanisms of Two Polysaccharides from Poria cocos. [PDF]

Molecules, 2023
Zhang W, He J, Zheng D, Zhao P, Wang Y, Zhao J, Li P.   +6 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

A Novel Hydrophilic Colloidal Polysaccharide from <i>Rosa roxburghii</i> Tratt: Structural Characterization, Rheological Behavior and Immunomodulatory Activity. [PDF]

Foods
Cui C, Wang M, Zhang Q, Zhang X, Zhu Q, Wang L, Li T, Zhu Z.   +7 more
europepmc   +1 more source

Structure Characterization and Immunomodulatory Activity of Misgurnus anguillicaudatus Carbohydrates. [PDF]

Molecules, 2023
Yun L, Han C, He X, Li Q, Fersht V, Zhang M.   +5 more
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Study on the Enrichment Effect of Suillus luteus Polysaccharide on Intestinal Probiotics and the Immunomodulatory Activity. [PDF]

Microorganisms
Ji H, Li M, Wang R, Mao D, Ji Z, Peng L, Ding W, Ji H.   +7 more
europepmc   +1 more source