Results 71 to 80 of about 20,086 (157)

Cytokine‐Driven Hyperinflammation in Long COVID: Mechanisms, Biomarkers, Complement Dysregulation, and Emerging Immunotherapies—A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Long COVID, also known as post‐acute sequelae of SARS‐CoV‐2 infection (PASC), is a multisystem condition characterized by persistent symptoms that continue beyond the acute phase of infection. Growing evidence indicates that sustained immune dysregulation involving cytokine‐mediated inflammation, complement activation ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

In silico evidence of monkeypox F14 as a ligand for the human TLR1/2 dimer

Frontiers in Immunology
Recent emergence of zoonotic monkeypox virus (Mpox) in human has triggered the virologists to develop plausible preventive measures. Hitherto, our understanding on the mechanism of immunopathogenesis of Mpox infection is elusive.
Ankita Chakraborty, Nabarun Chandra Das, Parth Sarthi Sen Gupta, Saroj Kumar Panda, Malay Kumar Rana, Srinivasa Reddy Bonam, Srinivasa Reddy Bonam, Jagadeesh Bayry, Suprabhat Mukherjee   +8 more
doaj   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Durability of response to icotrokinra for high‐impact site psoriasis: 1‐year ICONIC‐TOTAL findings

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 9, Page 1502-1514, September 2026.
Participants with at least moderate scalp, genital or hand/foot psoriasis receiving once‐daily oral icotrokinra achieved high, durable rates of overall and high‐impact site psoriasis clearance, showed substantial nail psoriasis improvement and exhibited no safety signals through 1 year, supporting icotrokinra use for long‐term management of high‐impact
Richard B. Warren, Melinda Gooderham, Edward Lain, Robert Bissonnette, Yu‐Huei Huang, Julien Ringuet, Matthias Hoffmann, Andreas Pinter, Joseph F. Merola, Jessica H. Rubens, Dorothy Fan, Ming‐Chun Hsu, Shu Li, Ya‐Wen Yang, Cynthia M. C. DeKlotz, Eingun James Song   +15 more
wiley   +1 more source

Large‐Scale Autoantibody Reactome Analysis Reveals Shared and Specific Signatures Across Different Immune‐Mediated Inflammatory Diseases

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective The shared and disease‐specific mechanisms across the immune‐mediated inflammatory diseases (IMIDs) spectrum remains incompletely characterized, despite the recognized role of autoantibodies as important indicators of immune tolerance breakdown and immune dysregulation. Methods Autoantibody reactome profiling of IgG and IgA autoantibodies was
Zhou Bai, Bomiao Yu, Zimo Wei, Pancheng Xiao, Minghua Zhan, Mansheng Li, Fang Wang, Yongjing Cheng, Minshu Zhao, Chao Zhang, Xuan Zhang, Xiaobo Yu, Yudong Liu   +12 more
wiley   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1548-1566, August 2026.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism

Tropical Medicine and Infectious Disease, 2018
Podoconiosis is an endemic, non-infectious, geochemical and non-filarial inflammatory cause of tropical elephantiasis. The immunology of podoconiosis is not yet expressly understood.
Damilare O. Famakinde, Adedotun A. Adenusi   +1 more
doaj   +1 more source

Overlap of Primary Biliary Cholangitis and Systemic Sclerosis: A Case of Reynolds Syndrome

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Reynolds Syndrome should be suspected in CREST patients with persistent cholestatic liver enzymes, since delayed diagnosis allows portal hypertension and variceal bleeding to develop. Early anti‐mitochondrial antibody screening and prompt ursodeoxycholic acid therapy improve outcomes, and these patients need multidisciplinary follow‐up for ...
Ali Gohar, Ira Abid, Syeda Eman Fatima, Abdum Muneeb Sandhu, Zain Fatima, Humayun Nasir, Fatima Arshad, Abdul Rehman Shahid Khan, Muhammad Husnain Ahmad, Masab Ali   +9 more
wiley   +1 more source

Immunopathogenic features of hemorrhagic fever with renal syndrome as criteria for early immunodiagnostics

RUDN Journal of Medicine
Relevance. Hemorrhagic fever with renal syndrome (HFRS) is a natural focal viral infection with a high probability of severe course, the possibility of death, a long recovery period after infection, low effectiveness of therapy and vaccine prevention. In
Michail F. Ivanov, Irina P. Balmasova, Elena S. Malova, Dmitriy Yu. Konstantinov   +3 more
doaj   +1 more source

Oral lichenoid lesions in CTLA‐4 haploinsufficiency: Targeting IFN‐γ‐driven mucosal immunopathology

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chen Wang, Laurie Brenchley, Teresa Greenwell‐Wild, Vasileios Ionas Theofilou, Timothy G. Myers, Chi A. Ma, Katherine Howe, Stefania Pittaluga, Steven M. Holland, Niki M. Moutsopoulos, David Fraser, Gulbu Uzel   +11 more
wiley   +1 more source