Results 71 to 80 of about 70,782 (340)

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma – the SKOPOS trial

OncoImmunology, 2018
Vaccines in combination with chemotherapy have been shown to be safe in different tumor types. We investigated the immunological activity of the TroVax® vaccine in combination with pemetrexed-cisplatin chemotherapy in malignant pleural mesothelioma (MPM).
Jason F Lester, Angela C Casbard, Saly Al-Taei, Richard Harrop, Lajos Katona, Richard L Attanoos, Zsuzsanna Tabi, Gareth O Griffiths   +7 more
doaj   +1 more source

Immunophenotypic dissection of normal hematopoiesis

Journal of Immunological Methods, 2019
Flow cytometry immunophenotyping is essential for diagnosis, classification and monitoring of clonal hematopoietic diseases, particularly of hematological malignancies and primary immunodeficiencies. Optimal use of immunophenotyping for these purposes requires detailed knowledge about the phenotypic patterns of normal hematopoietic cells.
Orfao, A., Matarraz, S., Perez-Andres, M., Almeida, J., Teodosio, C., Berkowska, M.A., Dongen, J.J.M. van, EuroFlow   +7 more
openaire   +5 more sources

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Microfluidic Device for On-Chip Immunophenotyping and Cytogenetic Analysis of Rare Biological Cells

Cells, 2020
The role of circulating plasma cells (CPCs) and circulating leukemic cells (CLCs) as biomarkers for several blood cancers, such as multiple myeloma and leukemia, respectively, have recently been reported.
Kumuditha M. Weerakoon-Ratnayake, Swarnagowri Vaidyanathan, Nicholas Larkey, Kavya Dathathreya, Mengjia Hu, Jilsha Jose, Shalee Mog, Keith August, Andrew K. Godwin, Mateusz L. Hupert, Malgorzata A. Witek, Steven A. Soper   +11 more
doaj   +1 more source

Role of immunophenotypes in carcinoma breast

International Journal of Applied and Basic Medical Research, 2018
Nottingham's modification of Bloom-Richardson histopathological grading system (NGS) for carcinoma breast is a time-tested prognostic indicator; however, of lately, breast cancer has been evaluated through molecular techniques, particularly assessing the gene expression profiling and establishing molecular or immunophenotypes.
Sunita Vagha, Pratibha Dawande, Ankita Tamhane, Samarth Shukla, Sourya Acharya   +4 more
openaire   +2 more sources

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

T lymphocyte subsets of the umbilical cord blood of dogs Subpopulações de linfócitos t no sangue de cordão umbilical de cães

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2009
The hematological parameters red blood cells (RBC) and total white blood cells (WBC) counts, hematocrit, hemoglobin concentration, and RBC indexes (median corpuscular volume and median corpuscular hemoglobin concentration) were determined and T CD5 ...
M.L.B. Cápua, A.E. Santana, A.P.M. Nakage, A.V. Godoy, A. Kataoka   +4 more
doaj   +1 more source

Transformation of acute lymphoblastic leukemia with a precursor B-cell immunophenotype to burkitt’s lymphoma: A case report [PDF]

Caspian Journal of Internal Medicine, 2023
Background: As a new point, some very rare features can be revealed as initial diagnosis of acute lymphoblastic leukemia (ALL) without any evidence of lymphoma-like behavior which after initial recovery, presents with new evidence of lymphoma.
Masoumeh Jafari, Shahla Ansari Damavandi, Forugh Charmduzi   +2 more
doaj  

In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment

Oncoimmunology, 2017
Despite aggressive treatment regimens based on surgery and radiochemotherapy, the prognosis of patients with grade IV glioblastoma multiforme (GBM) remains extremely poor, calling for alternative options such as immunotherapy.
G. Chitadze, C. Flüh, E. Quabius, S. Freitag-Wolf, C. Peters, M. Lettau, Jaydeep Bhat, D. Wesch, H. Oberg, Stefanie Luecke, O. Janssen, M. Synowitz, J. Held-Feindt, D. Kabelitz   +13 more
semanticscholar   +1 more source