Results 81 to 90 of about 45,883 (301)

Image3_Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune Microenvironment.pdf

, 2021
Background: The tumor microenvironment affects the occurrence and development of cancers, including clear cell renal cell carcinoma (ccRCC). However, how the immune contexture interacts with the cancer phenotype remains unclear.Methods: We identified and
Dingwei Ye (691205), Wangrui Liu (10028987), Chunguang Ma (10028990), Jiaqi Su (312162), Yuanyuan Qu (136533), Hong Xu (71477), Xi Tian (1526896), Hailiang Zhang (691203), Aihetaimujiang Anwaier (10028984), Wenkai Zhu (6428540), Wenhao Xu (2302681), Guohai Shi (691204), Shiyin Wei (11795672)   +12 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Table6_Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune Microenvironment.xlsx

, 2021
Background: The tumor microenvironment affects the occurrence and development of cancers, including clear cell renal cell carcinoma (ccRCC). However, how the immune contexture interacts with the cancer phenotype remains unclear.Methods: We identified and
Dingwei Ye (691205), Wangrui Liu (10028987), Chunguang Ma (10028990), Jiaqi Su (312162), Yuanyuan Qu (136533), Hong Xu (71477), Xi Tian (1526896), Hailiang Zhang (691203), Aihetaimujiang Anwaier (10028984), Wenkai Zhu (6428540), Wenhao Xu (2302681), Guohai Shi (691204), Shiyin Wei (11795672)   +12 more
core   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Preservation of functionality, immunophenotype, and recovery of HIV RNA from PBMCs cryopreserved for more than 20 years

Frontiers in Immunology
BackgroundMany research laboratories have long-term repositories of cryopreserved peripheral blood mononuclear cells (PBMC), which are costly to maintain but are of uncertain utility for immunological studies after decades in storage.
Wayne B. Dyer, Wayne B. Dyer, Kazuo Suzuki, Angelique Levert, Mitchell Starr, Andrew R. Lloyd, John J. Zaunders   +6 more
doaj   +1 more source

Immunophenotyping and Gene Rearrangement Analysis in Dogs with Lymphoproliferative Disorders Characterized by Small-Cell Lymphocytosis

, 2009
Lymphocytosis caused by neoplastic proliferation of small lymphocytes is occasionally difficult to distinguish by morphological examination from nonneoplastic lymphocytosis.
Tsukimi Washizu, Mayu Isotani, Ayumi Koike, Makoto Bonkobara, Hiroko Yagihara, Yosuke Uematsu, Kyoichi Tamura, Kenichiro Ono, Tomohiro Yamaguchi   +8 more
core   +1 more source

Table1_Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune Microenvironment.xlsx

, 2021
Background: The tumor microenvironment affects the occurrence and development of cancers, including clear cell renal cell carcinoma (ccRCC). However, how the immune contexture interacts with the cancer phenotype remains unclear.Methods: We identified and
Dingwei Ye (691205), Wangrui Liu (10028987), Chunguang Ma (10028990), Jiaqi Su (312162), Yuanyuan Qu (136533), Hong Xu (71477), Xi Tian (1526896), Hailiang Zhang (691203), Aihetaimujiang Anwaier (10028984), Wenkai Zhu (6428540), Wenhao Xu (2302681), Guohai Shi (691204), Shiyin Wei (11795672)   +12 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease

Frontiers in Immunology, 2017
Chronic graft-versus-host disease (cGVHD) is a debilitating complication arising in around half of all patients treated with an allogeneic hematopoietic stem cell transplantation. Even though treatment of severe cGVHD has improved during recent years, it
Arwen Stikvoort, Yang Chen, Emelie Rådestad, Johan Törlén, Johan Törlén, Tadepally Lakshmikanth, Andreas Björklund, Jaromir Mikes, Adnane Achour, Adnane Achour, Jens Gertow, Berit Sundberg, Mats Remberger, Mikael Sundin, Mikael Sundin, Jonas Mattsson, Jonas Mattsson, Petter Brodin, Petter Brodin, Michael Uhlin, Michael Uhlin, Michael Uhlin   +21 more
doaj   +1 more source

Flow cytometry immunophenotyping for diagnosis of myelodysplastic syndrome.

, 2009
In this perspective article, Dr. Cazzola examines standard and novel tools for the diagnosis of myelodysplastic syndrome. Flow cytometry immunophenotyping may provide complementary information in the diagnostic approach to a patient with this ...
CAZZOLA, MARIO
core   +1 more source