Results 71 to 80 of about 45,883 (301)

HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection

Frontiers in Immunology
IntroductionTuberculosis (TB) is the deadliest infectious disease worldwide and novel vaccines are urgently needed. HLA-E is a virtually monomorphic antigen presentation molecule and is not downregulated upon HIV co-infection.
Linda Voogd, Catherine Riou, Catherine Riou, Thomas J. Scriba, Marjolein van Wolfswinkel, Krista E. van Meijgaarden, Kees L. M. C. Franken, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Tom H. M. Ottenhoff, Simone A. Joosten   +12 more
doaj   +1 more source

Extremely low viral reservoir in treated chronically HIV-1-infected individuals

EBioMedicine, 2020
Background: Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV+ individuals could naturally also harbour low viral reservoirs.
Cristina Gálvez, Victor Urrea, Judith Dalmau, Montse Jimenez, Bonaventura Clotet, Valérie Monceaux, Nicolas Huot, Lorna Leal, Victoria González-Soler, Maria González-Cao, Michaela Müller-Trutwin, Asier Sáez-Cirión, Felipe García, Julià Blanco, Javier Martinez-Picado, Maria Salgado   +15 more
doaj   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

P601: TP53 ANALYSIS AND REPORTING IN CHRONIC LYMPHOCYTIC LEUKAEMIA: ARE LABORATORIES IN COMPLIANCE WITH THE EUROPEAN RESEARCH INITIATIVE ON CLL (ERIC) RECOMMENDATIONS?

HemaSphere, 2022
A. Cartwright, S. Scott, L. Whitby
doaj   +1 more source

Health technology assessment-based approach to flow cytometric immunophenotyping of acute leukemias: a literature classification

, 2020
Acute leukemia (AL) is a broad, heterogeneous group of malignant diseases. The diagnostic workup of AL is based on several clinical and laboratory findings, including flow cytometric immunophenotyping.
Mazzini G., Maglia O., Lanza F., Arpinati, Mario, Ciriello M. M., Mazzini, Giuliano, Venditti, Adriano, Pistotti V., Maglia, Oscar, Ciriello, Maria Matilde, Apolone, Giovanni, Buldini, Barbara, Riccioni, Roberta, Buldini B., Specchia G., Danova, Marco, Erba, Eugenio, Riccioni R., Pistotti, Vanna, Apolone G., Gaipa, Giuseppe, Kunkl A., Gaipa G., Erba E., Venditti A., Kunkl, Annalisa, Arpinati M., Mannelli F., Danova M., Mannelli, Francesco, Lanza, Francesco, Specchia, Giorgina   +31 more
core   +1 more source

Table7_Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune Microenvironment.xlsx

, 2021
Background: The tumor microenvironment affects the occurrence and development of cancers, including clear cell renal cell carcinoma (ccRCC). However, how the immune contexture interacts with the cancer phenotype remains unclear.Methods: We identified and
Dingwei Ye (691205), Wangrui Liu (10028987), Chunguang Ma (10028990), Jiaqi Su (312162), Yuanyuan Qu (136533), Hong Xu (71477), Xi Tian (1526896), Hailiang Zhang (691203), Aihetaimujiang Anwaier (10028984), Wenkai Zhu (6428540), Wenhao Xu (2302681), Guohai Shi (691204), Shiyin Wei (11795672)   +12 more
core   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

PB1854: NEXT GENERATION SEQUENCING APPROACHES IN CHRONIC LYMPHOCYTIC LEUKAEMIA: FINDINGS FROM EXTERNAL QUALITY ASSESSMENT

HemaSphere, 2022
A. Cartwright, H. Whitehouse, D. Travis, H. J. Clouston, S. Scott, L. Whitby   +5 more
doaj   +1 more source

Microglia immunophenotyping in gliomas

Oncology Letters, 2017
Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell proliferation and migration.
Annovazzi, Laura, Mellai, Marta, Bovio, Enrica, Mazzetti, Samanta, Pollo, Bianca, Schiffer, Davide   +5 more
openaire   +3 more sources