Results 81 to 90 of about 70,782 (340)

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

Advanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang, Wen‐Chi Xue, Chao Liang, Pan Liu, Yao Lei, Jiaqi He, Ran Cheng, Weidong Nie, Jianxiong Wang, Jie Tang, Hai‐Yan Xie   +10 more
wiley   +1 more source

Preservation of functionality, immunophenotype, and recovery of HIV RNA from PBMCs cryopreserved for more than 20 years

Frontiers in Immunology
BackgroundMany research laboratories have long-term repositories of cryopreserved peripheral blood mononuclear cells (PBMC), which are costly to maintain but are of uncertain utility for immunological studies after decades in storage.
Wayne B. Dyer, Wayne B. Dyer, Kazuo Suzuki, Angelique Levert, Mitchell Starr, Andrew R. Lloyd, John J. Zaunders   +6 more
doaj   +1 more source

Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry

International Journal of Molecular Sciences, 2016
The monitoring of immune cells gained great significance in prognosis and prediction of therapy responses. For analyzing blood samples, the multicolor flow cytometry has become the method of choice as it combines high specificity on single cell level ...
P. Rühle, R. Fietkau, U. Gaipl, B. Frey
semanticscholar   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

PB1854: NEXT GENERATION SEQUENCING APPROACHES IN CHRONIC LYMPHOCYTIC LEUKAEMIA: FINDINGS FROM EXTERNAL QUALITY ASSESSMENT

HemaSphere, 2022
A. Cartwright, H. Whitehouse, D. Travis, H. J. Clouston, S. Scott, L. Whitby   +5 more
doaj   +1 more source

EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes

Leukemia, 2012
Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on expert opinions, but they have not been validated. Here we present the validated EuroFlow 8-color antibody panels for immunophenotyping of hematological malignancies.
J. Dongen, L. Lhermitte, S. Böttcher, J. Almeida, V. V. D. Velden, J. Flores-Montero, A. Rawstron, V. Asnafi, Q. Lecrevisse, P. Lúcio, E. Mejstrikova, T. Szczepański, T. Kalina, R. Tute, M. Brüggemann, L. Sędek, M. Cullen, A. Langerak, Alexandre de Mendonça, E. Macintyre, M. Martín-Ayuso, O. Hrušák, M. Vidriales, A. Órfão   +23 more
semanticscholar   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

P601: TP53 ANALYSIS AND REPORTING IN CHRONIC LYMPHOCYTIC LEUKAEMIA: ARE LABORATORIES IN COMPLIANCE WITH THE EUROPEAN RESEARCH INITIATIVE ON CLL (ERIC) RECOMMENDATIONS?

HemaSphere, 2022
A. Cartwright, S. Scott, L. Whitby
doaj   +1 more source

Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4+ T cells, and disease activity

Scientific Reports, 2016
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to destructive arthritis. Although the HLA class II locus is the strongest genetic risk factor for rheumatoid arthritis, the relationship between HLA class II alleles and ...
Y. Nagafuchi, H. Shoda, S. Sumitomo, S. Nakachi, R. Kato, Y. Tsuchida, H. Tsuchiya, Keiichi Sakurai, N. Hanata, S. Tateishi, H. Kanda, K. Ishigaki, Y. Okada, A. Suzuki, Y. Kochi, K. Fujio, Kazuhiko Yamamoto   +16 more
semanticscholar   +1 more source

Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes

Arthritis &Rheumatology, EarlyView.
Objective To assess the relationship of circulating and synovial immune cells with synovial molecular pathology and disease outcomes in patients with early rheumatoid arthritis (RA). Methods Patients with early (<12 months) treatment‐naive RA (n = 144) from the Pathobiology of Early Arthritis Cohort were included in this post hoc analysis.
Felice Rivellese, Elena Pontarini, Liliane Fossati‐Jimack, Rita A. Moura, Vasco C. Romão, João Eurico Fonseca, Alessandra Nerviani, Cankut Çubuk, Katriona Goldmann, Giovanni Giorli, Myles Lewis, Michele Bombardieri, Costantino Pitzalis, on behalf of the Pathobiology of Early Arthritis Cohort (PEAC) investigators   +13 more
wiley   +1 more source