Results 151 to 160 of about 1,268 (176)

Experience with neonatal screening for cystic fibrosis in New Zealand using measurement of immunoreactive trypsinogen

Journal of Paediatrics and Child Health, 1989
Abstract Neonatal cystic fibrosis (CF) screening has been performed in New Zealand for a total of 7 years. This study reports the experience with this procedure in New Zealand over a 4 year period and compares it with 2 years when diagnoses of CF were suggested by clinical features only. A total of 72 infants were confirmed as having CF during 4 years
A W, Wesley, P A, Smith, R B, Elliott
exaly   +3 more sources

Generation and characterization of murine monoclonal antibodies against immunoreactive trypsinogen for newborn screening of cystic fibrosis

Analytical Biochemistry, 2020
Cystic fibrosis (CF) is a multisystem disorder that reduces quality of life and survival in affected individuals. In newborns, the release of pancreatic enzymes into the blood raises the levels of immunoreactive trypsinogen (IRT), the main marker for CF screening, which is detected in dried blood samples on filter paper by immunoenzymatic assays.
Iria Garcia De La Rosa
exaly   +3 more sources

Non-specific elevation of immunoreactive trypsinogen in sick infants

European Journal of Pediatrics, 1993
To determine the effect of neonatal illness on immunoreactive trypsinogen (IRT) levels, the IRT values obtained in sick infants transferred to a neonatal intensive care ward were compared with those found in matched controls. IRT levels from dried blood spots collected on day 4-5 of life from 372 sick infants had a mean value of 0.095 log transformed ...
D, Ravine, R I, Francis, D M, Danks
openaire   +2 more sources

Serum samples from pancreatectomized patients contain trypsinogen immunoreactivity

Journal of Laboratory and Clinical Medicine, 1996
The concentrations of trypsinogen-1 and -2 in serum samples from patients who have undergone pancreatectomy were measured by highly sensitive and specific time-resolved immunofluorometric assays. The isoenzyme pattern was determined by ion-exchange chromatography and determination of immunoreactivity in the fractions.
O, Itkonen, U H, Stenman, S, Osman, E, Koivunen, H, Halila, T, Schröder   +5 more
openaire   +2 more sources

Development and characterization of dried blood spot materials for the measurement of immunoreactive trypsinogen

Journal of Medical Screening, 2006
Objectives: In response to increasing numbers of states in the US that test newborn babies for cystic fibrosis (CF), the Newborn Screening Quality Assurance Programme initiated a pilot proficiency testing programme for immunoreactive trypsinogen (IRT), the biomarker for CF.
Lixia, Li, Yingtao, Zhou, Carol J, Bell, Marie C, Earley, W Harry, Hannon, Joanne V, Mei   +5 more
openaire   +2 more sources

Neonatal Infection Does Not Affect the Immunoreactive Trypsinogen Screening Test for Cystic Fibrosis

Journal of Pediatric Gastroenterology and Nutrition, 1994
SummaryWe aimed to discover whether neonatal infection affected levels of the immunoreactive trypsin (IRT) assay, which is used as a screening test for cystic fibrosis. Forty babies who had clinical features suggesting infection had blood spot specimens for IRT taken at the same time as blood for culture.
D C, Wilson, H, Leslie, J D, Edgar, H L, Halliday, J A, Dodge   +4 more
openaire   +2 more sources

Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: Evidence of pancreatic damage

The Journal of Pediatrics, 1985
We used a sensitive probe of pancreatic dysfunction, serum immunoreactive cationic trypsinogen, to study 50 infants and children with varying degrees of malnutrition. Patients were classified into subgroups according to the severity of malnutrition.
P R, Durie, G G, Forstner, K J, Gaskin, Z, Weizman, H R, Kopelman, L, Ellis, C, Largman   +6 more
openaire   +2 more sources

Immunoreactive trypsinogen screening for cystic fibrosis: Characterization of infants with a false‐positive screening test

Pediatric Pulmonology, 1989
AbstractBlood immunoreactive trypsinogen (IRT) is elevated in newborns with cystic fibrosis (CF) and has been used as a neonatal screening test. However, not only is the benefit of early diagnosis unknown, but also the sensitivity, specificity, and time related decline of IRT values have yet to be comprehensively evaluated.
M J, Rock, E H, Mischler, P M, Farrell, W T, Bruns, D J, Hassemer, R H, Laessig   +5 more
openaire   +2 more sources

Presence of Pancreatic α-Amylase, Trypsinogen, and Lipase Immunoreactivity in Normal Human Pancreatic Ducts

Pancreas, 1994
Presence of pancreatic alpha-amylase, trypsinogen, and lipase in normal pancreatic ducts was evaluated immunohistochemically in 10 surgically resected normal pancreatic specimens, using monoclonal antibodies against human pancreatic alpha-amylase, trypsinogen, and lipase.
T, Ohta, T, Terada, T, Nagakawa, H, Itoh, H, Tajima, I, Miyazaki   +5 more
openaire   +2 more sources

Newborn Screening for Cystic Fibrosis Is Complicated by Age-Related Decline in Immunoreactive Trypsinogen Levels

Pediatrics, 1990
Detection of elevated levels of immunoreactive trypsinogen (IRT) in dried neonatal blood spots has been used as a screening test for cystic fibrosis. In other cystic fibrosis newborn-screening studies, a sweat chloride test is generally performed only if an infant has a persistent IRT level above a selected cutoff value on both the initial and ...
M J, Rock, E H, Mischler, P M, Farrell, L J, Wei, W T, Bruns, D J, Hassemer, R H, Laessig   +6 more
openaire   +2 more sources