Results 1 to 10 of about 8,341 (178)

Minigenes for heterologous expression of human and mouse cationic trypsinogen. [PDF]

PLoS ONE
Inborn mutations in the PRSS1 gene encoding human cationic trypsinogen cause hereditary pancreatitis. In mouse models, PRSS1 mutations are often studied in the context of the Prss3b gene that codes for mouse cationic trypsinogen.
Gergő Berke, Miklós Sahin-Tóth
doaj   +3 more sources

Pancreatitis-associated chymotrypsin C (CTRC) variant p.R240Q selectively impairs trypsinogen degradation through disruption of long-range electrostatic interactions [PDF]

Scientific Reports
The digestive enzyme chymotrypsin C (CTRC) protects against chronic pancreatitis (CP) by promoting degradation of trypsinogen and thereby suppressing harmful intrapancreatic trypsin activity.
Zoltán Attila Nagy, Máté Sándor, Eszter Hegyi, Radovan Juríček, Gabriela Hrčková, Miklós Sahin-Tóth   +5 more
doaj   +2 more sources

Engineering mouse chymotrypsin B1 for improved trypsinogen degradation [PDF]

Scientific Reports
The digestive protease chymotrypsin (CTR) protects the pancreas against harmful trypsin activity by promoting degradation of trypsinogen. Recently, we demonstrated that Arg236 is responsible for the higher proteolytic activity and better trypsinogen ...
Nataly C. Morales Granda, András Szabó, Zsombor Köller, Gábor Pál, Miklós Sahin-Tóth   +4 more
doaj   +2 more sources

Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes [PDF]

BMJ Open Diabetes Research & Care
Introduction Altered serum levels of growth hormones, adipokines, and exocrine pancreas enzymes have been individually linked with type 1 diabetes (T1D).
Desmond Schatz, Laura Jacobsen, Todd M Brusko, Michael J Haller, Mark Atkinson, MacKenzie D Williams, Catherine Ramsey Grace, Amanda L Posgai, Kieran M McGrail, Maigan A Brusko, Rhonda Bacher, Clive H Wasserfall   +11 more
doaj   +2 more sources

Geniposide, a potential therapeutical candidate for acute pancreatitis, inhibited trypsinogen-activated CBS degradation and remodeled transsulfuration metabolic flux [PDF]

Redox Biology
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options currently available. The premature activation of trypsinogen within acinar cells constitutes one of the pivotal early pathological events in AP, contributing to ...
Ji Gao, Yijing Long, Jiawang Li, Yiqin Wang, Rui Wang, Jinxi Yang, Jie Zhang, Chenxia Han, Qing Xia, Dan Du   +9 more
doaj   +2 more sources

Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis [PDF]

Nature Communications
Acute pancreatitis (AP) is characterised by self-digestion of the pancreas by its own proteases. This pathophysiological initiating event in AP occurs inside pancreatic acinar cells where intrapancreatic trypsinogen becomes prematurely activated by ...
Jana Marielle Modenbach, Christina Möller, Saeedeh Asgarbeik, Norman Geist, Niklas Rimkus, Mark Dörr, Hannes Wolfgramm, Leif Steil, Anne Susemihl, Leonie Graf, Ole Schmöker, Dominique Böttcher, Elke Hammer, Juliane Glaubitz, Michael Lammers, Mihaela Delcea, Uwe Völker, Ali Alexander Aghdassi, Markus M. Lerch, Frank Ulrich Weiss, Uwe T. Bornscheuer, Matthias Sendler   +21 more
doaj   +2 more sources

The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation

Biomolecules, 2022
Background: The pathogenesis of chronic pancreatitis is still unclear. Trypsinogen activation is an active factor in acute pancreatitis that has not been studied in the occurrence of chronic pancreatitis.
Wenchao Yao, Dankun Luo, Zhenyi Lv, Yang Yang, Liyi Wang, Biao Ma, Dongbo Xue, Chenjun Hao, Yingmei Zhang   +8 more
doaj   +1 more source

Immunoassay for trypsinogen-4

Analytical Biochemistry, 2022
Trypsin has been identified as a pancreatic protease comprising three isoenzymes, trypsin-1, -2, and -3. However, the gene for trypsinogen-3, PRSS3, also gives rise to additional variants, trypsinogen-4A and B, which differ from trypsinogen-3 only with respect to the leader-peptide part, and when activated are identical to trypsin-3.
Hannu Koistinen, Riitta Koistinen, Kristina Hotakainen, Anna Lempiäinen, Kalle Jokelainen, Martti Färkkilä, Ulf-Håkan Stenman   +6 more
openaire   +3 more sources

The importance of biomarker development for monitoring type 1 diabetes progression rate and therapeutic responsiveness

Frontiers in Immunology, 2023
Type 1 diabetes (T1D) is an autoimmune condition of children and adults in which immune cells target insulin-producing pancreatic β-cells for destruction. This results in a chronic inability to regulate blood glucose levels. The natural history of T1D is
Maxwell J. Fyvie, Kathleen M. Gillespie
doaj   +1 more source

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis

Molecular Medicine, 2022
Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou, Qiangqiang Fang   +4 more
doaj   +1 more source