Results 11 to 20 of about 8,341 (178)
HGG Advances, 2023 Summary: Phasing of heterozygous alleles is critical for interpretation of cis-effects of disease-relevant variation. We sequenced 477 individuals with cystic fibrosis (CF) using linked-read sequencing, which display an average phase block N50 of 4.39 Mb.
Scott Mastromatteo +35 more
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Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle
Cells, 2022 Recent studies have highlighted the importance of autophagy and particularly non-canonical autophagy in the development and progression of acute pancreatitis (a frequent disease with considerable morbidity and significant mortality).
Svetlana Voronina +6 more
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The Autoactivation of Trypsinogen
Journal of Biological Chemistry, 1971 The ability of trypsinogen to catalyze its own activation was studied at pH 8.1 in the presence of Ca++ ions. The lag phase portion of the classical S-shaped curve of activation was shortened by increasing the trypsinogen concentration but was extended by pretreatment of the zymogen with diisopropyl fluorophosphate or soybean trypsin inhibitor. Despite
J, Kay, B, Kassell
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Effect of dietary fat on pancreatic lipase levels in the rat
Journal of Lipid Research, 1973 The effect of dietary fat on levels of lipase and other enzymes in rat pancreas has been studied. It was possible to raise levels of lipase in animals by supplementing their commercial chow diet with added fat or by raising the level of fat in ...
Lewis I. Gidez
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Frequency of raised Urinary Trypsinogen-2 in Acute Pancreatitis
International Journal of Endorsing Health Science Research, 2016 Objectives: To determine the frequency of raised Urinary Trypsinogen-2 in diagnosed patients of acute pancreatitis. Methodology: Settings Patients in emergency refer to General Surgery ward-3 Jinnah Post Graduate and Medical Centre Karachi.
Mansab Ali +6 more
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A novel method for silkworm cocoons self-degumming and its effect on silk fibers
Journal of Advanced Research, 2023 Introduction: Conventional hot-alkaline cocoon degumming techniques greatly weaken the physicochemical and mechanical properties of silk fibroin fiber, thus affecting the quality of silk fabric.
Riyuan Wang +6 more
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Novel Pathogenic PRSS1 Variant p.Glu190Lys in a Case of Chronic Pancreatitis
Frontiers in Genetics, 2019 Mutations in the PRSS1 (serine protease 1) gene encoding human cationic trypsinogen cause hereditary pancreatitis or may be associated with sporadic chronic pancreatitis.
Zsanett Jancsó +6 more
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Reference Intervals for and Validation of Recalibrated Immunoassays for Trypsinogen-1 and Trypsinogen-2 [PDF]
Clinical Chemistry, 2012 To the Editor: Serum trypsinogen assays are used as diagnostic and prognostic tools for cystic fibrosis and acute pancreatitis (AP) (1, 2). Calibrator stability is a challenge in these assays, because trypsinogen readily autoactivates and subsequently autodegrades. Furthermore, the reference intervals described thus far have been based on samples from
Kylänpää Leena +5 more
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Cathepsin B cleavage of the trypsinogen activation peptide
BMC Gastroenterology, 2002 Background Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and ...
Keim Volker, Bödeker Hans, Teich Niels
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Elevated newborn serum immunoreactive trypsinogen associated with a congenital pancreatic cyst
Journal of Pediatric Surgery Case Reports, 2021 Congenital abdominal cysts have a broad differential diagnosis. Pancreatic cysts are rare lesions that offer a diagnostic and surgical challenge to surgeons.
Fabio Botelho +2 more
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