Results 21 to 30 of about 8,341 (178)

Evolution of Trypsinogen Activation Peptides [PDF]

Molecular Biology and Evolution, 2003
The activation peptide of mammalian trypsinogens contains a highly conserved tetra-aspartate sequence (D19-D20-D21-D22) preceding the K23-I24 scissile peptide bond, which is hydrolyzed as the first step in the activation process. Here, we examined the evolution and function of trypsinogen activation peptides through integrating functional ...
Jian-Min, Chen, Zoltán, Kukor, Cédric, Le Maréchal, Miklós, Tóth, Laurent, Tsakiris, Odile, Raguénès, Claude, Férec, Miklós, Sahin-Tóth   +7 more
openaire   +2 more sources

Trypsinogen isoforms in the ferret pancreas [PDF]

Scientific Reports, 2018
AbstractThe domestic ferret (Mustela putorius furo) recently emerged as a novel model for human pancreatic diseases. To investigate whether the ferret would be appropriate to study hereditary pancreatitis associated with increased trypsinogen autoactivation, we purified and cloned the trypsinogen isoforms from the ferret pancreas and studied their ...
Eszter Hegyi, Miklós Sahin-Tóth
openaire   +2 more sources

Diagnostic and Prognostic Utility of C-reactive Protein and Urinary Trypsinogen Activation Biomarkers in Acute Pancreatitis: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research
Acute Pancreatitis (AP) is a leading gastrointestinal cause of hospital admission and has an unpredictable early course. Although most cases are mild, a subset progresses to necrosis and/or persistent organ failure with substantial morbidity and ...
B Pooja, Samir Ahmad, Manivannan Rajarathinam, Guru Prasad Narayanan   +3 more
doaj   +1 more source

The lncRNA TCONS_00021785/miR-21-5p/Trim33 axis regulates VMP1-mediated zymophagy, reduces the activation of trypsinogen, and promotes acinar cell recovery

Cell Death Discovery, 2022
In the early stage of acute pancreatitis, trypsinogen in acinar cells is activated, and the cells clear trypsin through zymophagy to avoid damage. Studies have shown that the substrate of zymophagy is ubiquitinated pancreatin, but the mechanism of ...
Qiang Wang, Jingjing Yu, Wenqi Gao, Yuanyuan Sun, Xuxu Liu, Zhenyi Lv, Long Li, Dongbo Xue   +7 more
doaj   +1 more source

Human trypsinogen in colorectal cancer [PDF]

International Journal of Cancer, 2001
Trypsinogen (TRY), the precursor to the serine protease trypsin, is found in the pancreas and mediates digestive proteolysis in the small intestine. Differential display of cDNAs expressed by human colorectal tumor tissues compared with adjacent normal colonic mucosa identified an isoform of TRY (TRY2) up-regulated in colorectal cancers.
Williams, SJ, Gotley, DC, Antalis, TM
openaire   +5 more sources

Biliary hCGβ Is a Potential Novel Marker for Prediction of Biliary Neoplasia in Primary Sclerosing Cholangitis Patients

Livers, 2021
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease, which is associated with an increased risk of cholangiocarcinoma (CCA). Novel markers, to complement or replace CA19-9, are urgently needed for the screening of PSC-associated ...
Hannu Koistinen, Sonja Boyd, Johanna Arola, Kalle Jokelainen, Riitta Koistinen, Anna Lempiäinen, Kristina Hotakainen, Ulf-Håkan Stenman, Martti Färkkilä   +8 more
doaj   +1 more source

Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes.

PLoS ONE, 2009
We have developed a protocol to assemble in one step and one tube at least nine separate DNA fragments together into an acceptor vector, with 90% of recombinant clones obtained containing the desired construct.
Carola Engler, Ramona Gruetzner, Romy Kandzia, Sylvestre Marillonnet   +3 more
doaj   +1 more source

Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice. [PDF]

PLoS ONE, 2018
Clinical studies have shown that cigarette smoking is a dose-dependent and independent risk factor for acute pancreatitis. Cigarette smoke contains nicotine which can be converted to the potent receptor ligand and toxin, NNK [4-(methylnitrosamino)-1-(3 ...
A A Alahmari, B Sreekumar, V Patel, M Ashat, M Alexandre, A K Uduman, E O Akinbiyi, A Ceplenski, C A Shugrue, T R Kolodecik, N Tashkandi, S W Messenger, G E Groblewski, F S Gorelick, E C Thrower   +14 more
doaj   +1 more source

Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

Veterinární Medicína, 2019
The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides
Zuhair Bani Ismail, Ahmad Mahmmoud Al-Majali, Odeh Al-Rawashdeh, Mousa Daradka, Musaab Mohaffel   +4 more
doaj   +1 more source

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium. [PDF]

PLoS ONE, 2013
Several deleterious intra-acinar phenomena are simultaneously triggered on initiating acute pancreatitis. These culminate in acinar injury or inflammatory mediator generation in vitro and parenchymal damage in vivo. Supraphysiologic caerulein is one such
Vivek Mishra, Rachel Cline, Pawan Noel, Jenny Karlsson, Catherine J Baty, Lidiya Orlichenko, Krutika Patel, Ram Narayan Trivedi, Sohail Z Husain, Chathur Acharya, Chandra Durgampudi, Donna B Stolz, Sarah Navina, Vijay P Singh   +13 more
doaj   +1 more source