Results 81 to 90 of about 1,268 (176)

Initial Evaluation of Prospective and Parallel Assessments of Cystic Fibrosis Newborn Screening Protocols in Eastern Andalusia: IRT/IRT versus IRT/PAP/IRT

International Journal of Neonatal Screening, 2019
Identifying newborns at risk for cystic fibrosis (CF) by newborn screening (NBS) using dried blood spot (DBS) specimens provides an opportunity for presymptomatic detection. All NBS strategies for CF begin with measuring immunoreactive trypsinogen (IRT).
Ilham Sadik, Inmaculada Pérez de Algaba, Rocío Jiménez, Carmen Benito, Javier Blasco-Alonso, Pilar Caro, Víctor M. Navas-López, Javier Pérez-Frías, Estela Pérez, Juliana Serrano, Raquel Yahyaoui   +10 more
doaj   +1 more source

Exploring Turkey's mosaic of novel variants and complex alleles in cystic fibrosis genetics

Pediatric Pulmonology, Volume 59, Issue 12, Page 3540-3549, December 2024.
Abstract Backgrounds Genetic variants in CF transmembrane conductance regulator (CFTR) gene causes cystic fibrosis (CF), a prevalent autosomal recessive disorder. More than 2000 variants in CFTR have been described as disease causative. This study aims to delineate the genotypic and phenotypic landscape of CF among people with CF (pwCF) followed at the
Ceren Ayça Yıldız, Merve Selçuk Balcı, Şeyda Karabulut, Zeynep Münteha Başer, Mine Kalyoncu, Neval Metin Çakar, Müge Merve Akkitap Yiğit, Eda Esra Baysal, Fulya Özdemircioğlu, Burcu Uzunoğlu, Gamze Taştan, Pınar Ergenekon, Yasemin Gökdemir, Ela Erdem Eralp, Fazilet Karakoç, Pınar Ata, Bülent Karadağ   +16 more
wiley   +1 more source

Trypsin activity. A new marker of acute alcoholic pancreatitis [PDF]

, 1994
A normal serum amylase level is found in up to 32% of patients with acute alcoholic pancreatitis. This underlines the need for more sensitive diagnostic tests in this frequent cause of pancreatitis.
Michel Cremer, Cremer, Michel, Jacques Devière, Philippe Thiry, Le Moine, Olivier, Ooms, Henri, Devière, Jacques, Thiry, Philippe, Henri-Albert Ooms, Jeanne-Marie Devaster, Devaster, Jeanne-Marie, Olivier Le Moine   +11 more
core   +1 more source

Pancreas and pancreatitis: Exocrine pancreatic insufficiency

Pediatric Pulmonology, Volume 59, Issue S1, Page S44-S52, September 2024.
Abstract Exocrine pancreatic insufficiency (EPI) is highly prevalent among individuals with cystic fibrosis (CF). Individuals diagnosed with EPI are often labeled as having “pancreas insufficient cystic fibrosis (PI‐CF)” while those with normal exocrine function are labeled as “pancreas sufficient CF (PS‐CF).” This diagnosis of EPI relies on clinical ...
Mitchell L. Ramsey, Gary J. Galante
wiley   +1 more source

Involvement of heparanase in the pathogenesis of acute pancreatitis: Implication of novel therapeutic approaches

Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.
Abstract Acute pancreatitis (AP) is a common gastrointestinal disease with high morbidity and mortality rate. Unfortunately, neither the etiology nor the pathophysiology of AP are fully understood and causal treatment options are not available. Recently we demonstrated that heparanase (Hpa) is adversely involved in the pathogenesis of AP and inhibition
Dalit B. Hamo‐Giladi, Ahmad Fokra, Edmond Sabo, Aviva Kabala, Irena Minkov, Shadi Hamoud, Salim Hadad, Zaid Abassi, Iyad Khamaysi   +8 more
wiley   +1 more source

Characterization of immunoreactive trypsinogen activation peptide in urine in acute pancreatitis.

JOP : Journal of the pancreas, 2006
All work on human trypsinogen activation peptide (TAP) in acute pancreatitis has been carried out with the same assay. Despite the extensive use of this original TAP assay, there is no characterization of the TAP-like immunoreactivity measured.The aims of this study were to develop an additional TAP assay and to attempt to characterize the TAP-like ...
Ulf, Petersson, Anders, Borgström
openaire   +1 more source

SHIFTing goals in cystic fibrosis—managing extrapulmonary disease in the era of CFTR modulator therapy; Proceedings of the International Shaping Initiatives and Future Trends (SHIFT) Symposium

Pediatric Pulmonology, Volume 59, Issue 6, Page 1661-1676, June 2024.
Abstract Background Cystic fibrosis (CF) is a life‐shortening multisystem genetic disease. Although progressive pulmonary disease is the predominant cause of morbidity and mortality, improvements in treatment for CF‐related lung disease, with associated increase in longevity, have increased the prevalence of extrapulmonary manifestations1.
Jonathan E. M. O'Donnell, Lucy A. Hastings, Julie N. Briody, Christine L. Chan, Carla Colombo, Tonia A. Douglas, Steven D. Freedman, Tanja Gonska, Jerry R. Greenfield, Daniel H. Leung, Adeline Y. L. Lim, Antoinette Moran, Bernadette J. Prentice, Melissa S. Putman, Michael Trotter, Elizabeth Tullis, Glen P. Westall, Charles F. Verge, Claire E. Wainwright, Chee Y. Ooi, the SHIFT Symposium 2021, John F. Engelhardt, Tamarah Katz, Susannah King, Peter J. Lewindon, Angela G. Matson, Catherine M. McDonald, Amir Moheet, Michael R. Narkewicz, Mark Oliver, Grant A. Ramm, Zachary M. Sellers, Michael Wilschanski   +32 more
wiley   +1 more source

Newborn cystic fibrosis screening in southeastern Mexico: Birth prevalence and novel CFTR gene variants [PDF]

, 2017
Objective To use the results of the first five years of a cystic fibrosis newborn screening program to estimate the cystic fibrosis birth prevalence and spectrum of cystic fibrosis transmembrane conductance regulator ( CFTR) gene variants in Yucatan ...
Claudia-Margarita Moreno-Graciano, Luz del Alba Herrera-Pérez, Marcela Vela-Amieva, Isabel Ibarra-González, Silvina-Noemí Contreras-Capetillo, Miguel Angel Alcántara-Ortigoza, Verónica León-Burgos, Ariadna González del Angel, Patricia Martínez-Cruz, Felipe-Angel Maldonado-Solis, Felix-Julián Campos-Garcia   +10 more
core   +1 more source

Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls [PDF]

, 1990
To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in
Kockum, K., Thilén, A., Segnestam, K., Bäckman, H., Neiderud, J., Mazreliez, V., Wall, S., Sjögren, S., Smith, T., Holmberg, E., Westphal, O., Samuelsson, G., Lindberg, U., Sigurs, N., Edenwall, H., Jonsell, G., Elfstrand, P. O., Myrdal, U., Carlsson, E., Granström, B. W., Tuvemo, T., Skogsberg, L., Lernmark, Ake, Jönsson, C., Sjöblad, S., Borgstrom, Anders, Hansing, B., The Swedish Childhood Diabetes Group, Blom, Leif, Petzén, P. G., Thalme, B., Gustavsson, I., Strömberg, L., Nilsson, K. O., Persson, B., Sundkvist, Goran, Hallberg, A., Hanås, R., Landin-Olsson, Mona, Ludvigsson, J., Tenstam, J., Snellman, K., Lindblad, B., Hellenberg, L., Gustavsson, L. E., Sandström, A., Hornell, H., Ståle, U., Aili, M., Tullus, K., Nyström, L.   +50 more
core   +3 more sources

Impact of heparanase‐2 (Hpa2) on cancer and inflammation: Advances and paradigms

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
(A) Clinical evidence in several types of cancer shows that Hpa2 is readily detected in normal epithelium, whereas its levels are decreased substantially in the resulting carcinomas. Importantly, patients exhibiting high levels of Hpa2 survived longer than patients showing low levels of Hpa2.
Israel Vlodavsky, Maram Hilwi, Yasmin Kayal, Soaad Soboh, Neta Ilan   +4 more
wiley   +1 more source