Results 151 to 160 of about 392,479 (342)

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Outcome After Steroid Withdrawal in Renal Transplant Patients Receiving Tacrolimus-Based Immunosuppression

, 1998
Ron Shapiro, Mark L. Jordan, Velma P. Scantlebury, Carlos Vivas, H. Albin Gritsch, J McCauley, Dwayne McQuitty, Parmjeet Randhawa, William Irish, John McMichael, T.R. Hakala, Richard L. Simmons, John J. Fung, Thomas E. Starzl   +13 more
openalex   +2 more sources

Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. [PDF]

, 1991
Robert Lanza, D H Butler, K. Borland, James E. Staruk, Denise L. Faustman, Barry A. Solomon, Thomas E. Müller, Randall G. Rupp, Takashi Maki, Anthony P. Monaco   +9 more
openalex   +1 more source

Restraint Stress-Induced Immunosuppression Is Associated with Concurrent Macrophage Pyroptosis Cell Death in Mice [PDF]

, 2023
Chi‐Cheng Li, Rina Munalisa, Hsuan-Yun Lee, Te-Sheng Lien, Hao Chan, Shih‐Che Hung, Der‐Shan Sun, Ching‐Feng Cheng, Hsin‐Hou Chang   +8 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients

Intensive Care Medicine Experimental, 2019
Charles de Roquetaillade, Khalil Kandara, Morgane Gossez, Estelle Peronnet, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Fabienne Venet   +9 more
doaj   +1 more source

Herbal Medicines for Immunosuppression

Iranian Journal of Allergy, Asthma and Immunology, 2012
Herbal medicines have been used for centuries to treat different illnesses. Among more than 20,000 herbal medicines available for humans, a limited number have sufficiently been studied and numerous remained to be investigated for their efficacy in ...
Zahra Amirghofran
doaj  

Advances in the understanding and treatment of sepsis-induced immunosuppression

Nature Reviews Nephrology, 2018
F. Venet, G. Monneret
semanticscholar   +1 more source

The role of dendritic cells (DC) in Friend retrovirus-induced immunosuppression and immunotherapeutic applications of functionalized nanoparticles

, 2014
Limei Shen
openalex   +1 more source