Results 311 to 320 of about 556,132 (392)

Towards curing type 1 diabetes: Prospects and challenges of allogeneic or xenogeneic donor islet cell transplantation. [PDF]

World J Transplant
Jiang H, Henley D, Jiang FX.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Belatacept Maintenance Immunosuppression for Calcineurin Inhibitor Sparing or Avoidance in Pancreas Transplant Recipients With Progressive Renal or Renal Allograft Dysfunction. [PDF]

Clin Transplant
Chen JM, Mangus RS, Sharfuddin AA, Powelson JA, Yaqub MS, Jan MY, Lutz AJ, Fridell JA.   +7 more
europepmc   +1 more source

Figure 4 from Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression

Malcolm F. McDonald, Rachel Naomi Curry, Isabella O’Reilly, Brittney Lozzi, Alexis Cervantes, Zhung-Fu Lee, Anna Rosenbaum, Peihao He, Carrie Mohila, Arif Harmanci, Akdes Serin Harmancı, Benjamin Deneen, Ganesh Rao   +12 more
openalex   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Incidence and Risk Factors for Surgical Site Infections in Pediatric Abdominal Surgery: A Multicenter Cohort Study.

J Pharm Bioallied Sci
Ankita, Xess NG, Tirkey K, Sahu SS, Ranjan A, Singh AK, Lakra PS, Birua H.   +7 more
europepmc   +1 more source

Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies. [PDF]

Viruses
Al-Saud AA, Abufarhaneh EH, Alsanea MS, Alameer RM, Yamani AH, Alhamlan FS, Almaghrabi RS.   +6 more
europepmc   +1 more source

Early Immunosuppression Conditioning Regimens For Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-analysis of Cytokine Release Syndrome Incidence

Pedraza, Perla Rocío Colunga, Alfaro, Héctor Alejandro Vaquera, De Las Fuentes Cepeda, Alejandra   +2 more
openalex   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source