Results 351 to 360 of about 556,132 (392)
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Psychosomatics, 2004
Immunosuppressants are prescribed to prevent rejection of transplanted tissues and organs and are also used in the treatment of autoimmune disorders. Consultation-liaison psychiatrists increasingly encounter patients taking these agents as the number of transplant recipients increases and the indications for the use of immunosuppressants expands. These
Marian, Fireman +3 more
openaire +2 more sources
Immunosuppressants are prescribed to prevent rejection of transplanted tissues and organs and are also used in the treatment of autoimmune disorders. Consultation-liaison psychiatrists increasingly encounter patients taking these agents as the number of transplant recipients increases and the indications for the use of immunosuppressants expands. These
Marian, Fireman +3 more
openaire +2 more sources
Gastroenterology Clinics of North America, 1992
The role and pharmacology of a variety of immunosuppressant agents in the gastrointestinal tract and liver are reviewed in this article. Immunosuppressants covered include cyclosporine, corticosteroids, OKT3, antithymocyte globulin, azathioprine, methotrexate, and FK506. Guidelines for the use and complications of immunosuppressants in liver, pancreas,
J W, Marsh, K L, Vehe, H M, White
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The role and pharmacology of a variety of immunosuppressant agents in the gastrointestinal tract and liver are reviewed in this article. Immunosuppressants covered include cyclosporine, corticosteroids, OKT3, antithymocyte globulin, azathioprine, methotrexate, and FK506. Guidelines for the use and complications of immunosuppressants in liver, pancreas,
J W, Marsh, K L, Vehe, H M, White
openaire +2 more sources
Immunosuppressive Cyclolignans
Journal of Medicinal Chemistry, 1996The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to
M, Gordaliza +5 more
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Clinics in Liver Disease, 2000
The current treatment of posttransplant lymphoproliferative disease (PTLD) includes prophylaxis at the time of transplant, decreasing or stopping immunosuppresion and initiation of antiviral therapy in patients with polymerase chain reaction or clinical evidence of PTLD, and judicial reintroduction of immunosuppression in patients who have cleared ...
D C, Cronin +6 more
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The current treatment of posttransplant lymphoproliferative disease (PTLD) includes prophylaxis at the time of transplant, decreasing or stopping immunosuppresion and initiation of antiviral therapy in patients with polymerase chain reaction or clinical evidence of PTLD, and judicial reintroduction of immunosuppression in patients who have cleared ...
D C, Cronin +6 more
openaire +2 more sources
Clinical Pharmacology & Therapeutics, 1974
In this paper, I propose to review some of the current concepts of development of immunocompetence, to describe the cellular events that follow exposure to antigen, and to show how these data may be applied to therapy with immunosuppressive drugs. The greatest emphasis will be placed on the glucocorticoids, because these agents are widely employed in ...
openaire +2 more sources
In this paper, I propose to review some of the current concepts of development of immunocompetence, to describe the cellular events that follow exposure to antigen, and to show how these data may be applied to therapy with immunosuppressive drugs. The greatest emphasis will be placed on the glucocorticoids, because these agents are widely employed in ...
openaire +2 more sources
ACS Nano, 2021
The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell ablation efficiency has received extensive interest in oncotherapy.
Na Tao +9 more
semanticscholar +1 more source
The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell ablation efficiency has received extensive interest in oncotherapy.
Na Tao +9 more
semanticscholar +1 more source
Pharmacologic immunosuppression
Frontiers in Bioscience, 2004Clinical organ transplantation only became a viable treatment option after the advent of effective pharmacologic immunosuppression. Azathioprine and steroids were among the first drugs available for pharmacologic immunosuppression allowed for the first long-term successes in kidney and liver transplantation, though survivors experienced significant ...
Neal R, Barshes +2 more
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Pediatric Transplantation, 2004
Abstract: Advances in maintenance immunosuppression over the past decade has resulted in dramatic improvements in short‐ and long‐term outcomes in organ transplantation as well as a decreased incidence of acute rejection. However, immunosuppressive drugs need to be given long term, lack specificity, and are accompanied by adverse metabolic ...
Nancy R, Krieger, Sukru, Emre
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Abstract: Advances in maintenance immunosuppression over the past decade has resulted in dramatic improvements in short‐ and long‐term outcomes in organ transplantation as well as a decreased incidence of acute rejection. However, immunosuppressive drugs need to be given long term, lack specificity, and are accompanied by adverse metabolic ...
Nancy R, Krieger, Sukru, Emre
openaire +2 more sources
Surgical Clinics of North America, 1994
The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses.
B D, Kahan, R, Ghobrial
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The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses.
B D, Kahan, R, Ghobrial
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Surgical Clinics of North America, 1999
Although several new immunosuppressive medications have been developed in the past decade, many possible avenues are yet to be explored. Although the newer agents have not reflected any clear benefit in patient or graft survival over CsA or tacrolimus, they have been useful in reducing the incidence and severity of rejection, reducing the concomitant ...
A, Jain +4 more
openaire +2 more sources
Although several new immunosuppressive medications have been developed in the past decade, many possible avenues are yet to be explored. Although the newer agents have not reflected any clear benefit in patient or graft survival over CsA or tacrolimus, they have been useful in reducing the incidence and severity of rejection, reducing the concomitant ...
A, Jain +4 more
openaire +2 more sources