Results 351 to 360 of about 521,863 (391)
Some of the next articles are maybe not open access.
Psychosomatics, 2004
Immunosuppressants are prescribed to prevent rejection of transplanted tissues and organs and are also used in the treatment of autoimmune disorders. Consultation-liaison psychiatrists increasingly encounter patients taking these agents as the number of transplant recipients increases and the indications for the use of immunosuppressants expands. These
Marian, Fireman +3 more
openaire +2 more sources
Immunosuppressants are prescribed to prevent rejection of transplanted tissues and organs and are also used in the treatment of autoimmune disorders. Consultation-liaison psychiatrists increasingly encounter patients taking these agents as the number of transplant recipients increases and the indications for the use of immunosuppressants expands. These
Marian, Fireman +3 more
openaire +2 more sources
Immunosuppression by Discodermolide
Annals of the New York Academy of Sciences, 1993In summary, discodermolide, a novel, marine-derived compound, is a potent in vitro and in vivo immunosuppressive agent. Discodermolide blocks cellular proliferation in lymphoid and nonlymphoid cells. This blocking action is not due to cytotoxicity. Blockage of cell proliferation by discodermolide appears to occur at the G2/M interface of the cell cycle,
Longley, R. E. +4 more
openaire +3 more sources
Clinical Pharmacology & Therapeutics, 1974
In this paper, I propose to review some of the current concepts of development of immunocompetence, to describe the cellular events that follow exposure to antigen, and to show how these data may be applied to therapy with immunosuppressive drugs. The greatest emphasis will be placed on the glucocorticoids, because these agents are widely employed in ...
openaire +2 more sources
In this paper, I propose to review some of the current concepts of development of immunocompetence, to describe the cellular events that follow exposure to antigen, and to show how these data may be applied to therapy with immunosuppressive drugs. The greatest emphasis will be placed on the glucocorticoids, because these agents are widely employed in ...
openaire +2 more sources
Trends in Pharmacological Sciences, 1993
Experimental models of autoimmune diseases have demonstrated that such disease can be prevented or treated by selectively interfering with activation of any of these cell types: antigen-presenting cells, autoreactive T cells and regulatory T cells. Luciano Adorini and colleagues discuss these approaches to selective immunosuppression and examine how ...
L, Adorini +3 more
openaire +3 more sources
Experimental models of autoimmune diseases have demonstrated that such disease can be prevented or treated by selectively interfering with activation of any of these cell types: antigen-presenting cells, autoreactive T cells and regulatory T cells. Luciano Adorini and colleagues discuss these approaches to selective immunosuppression and examine how ...
L, Adorini +3 more
openaire +3 more sources
2013
A variety of immunosuppressants and disease-modifying anti-rheumatic drugs (DMARDs) with beneficial effects on inflammatory rheumatic diseases have been identified over the last 50 years. Their use for these conditions is now well established and has led to considerable improvements in disease management.
Joanna Ledingham, Sarah Westlake
openaire +1 more source
A variety of immunosuppressants and disease-modifying anti-rheumatic drugs (DMARDs) with beneficial effects on inflammatory rheumatic diseases have been identified over the last 50 years. Their use for these conditions is now well established and has led to considerable improvements in disease management.
Joanna Ledingham, Sarah Westlake
openaire +1 more source
Immunosuppression for Myocarditis
New England Journal of Medicine, 1995The diagnosis of acute myocarditis has been a conundrum. One criterion is the clinical picture of the sudden onset of cardiac failure and arrhythmias, often associated with a febrile illness; the other criterion is a myocardial-biopsy specimen that shows a specified degree of myocyte damage and infiltration by T lymphocytes.
William J. McKenna, Michael J. Davies
openaire +3 more sources
Frontiers in Immunosuppression
Transplantation Proceedings, 2008Immunosuppressive therapy has relied on tailoring combinations of relatively nonselective drugs to individual patient tolerance. The next steps in the development of small molecule agents are to define and to develop selective inhibitors of cascades unique to T cells.
openaire +5 more sources
Infectious Disease Clinics of North America, 2012
This article reviews the normal immune response to vaccines. It describes the effect of different immunosuppressive therapies (glucocorticoids, inhibitors of calcineurin and mTOR, azathioprine, mycophenolate acid, methotrexate, depleting and nondepleting monoclonal antibodies, and tumor necrosis factor antagonists) on critical steps in the cellular and
openaire +3 more sources
This article reviews the normal immune response to vaccines. It describes the effect of different immunosuppressive therapies (glucocorticoids, inhibitors of calcineurin and mTOR, azathioprine, mycophenolate acid, methotrexate, depleting and nondepleting monoclonal antibodies, and tumor necrosis factor antagonists) on critical steps in the cellular and
openaire +3 more sources
Advances in Materials, 2020
Effective reversal of tumor immunosuppression is of critical importance in cancer therapy. A multifunctional delivery vector that can effectively deliver CRISPR‐Cas9 plasmid for β‐catenin knockout to reverse tumor immunosuppression is constructed.
Xiao-Yan He +7 more
semanticscholar +1 more source
Effective reversal of tumor immunosuppression is of critical importance in cancer therapy. A multifunctional delivery vector that can effectively deliver CRISPR‐Cas9 plasmid for β‐catenin knockout to reverse tumor immunosuppression is constructed.
Xiao-Yan He +7 more
semanticscholar +1 more source
Immunosuppression on the Horizon [PDF]
Heart Failure Clinics, 2007 Many novel immunosuppressive agents are under active clinical investigation. In addition, creative approaches are being developed for the use of established immunosuppressive agents, with the goal of minimizing immunosuppression as early as possible posttransplantation.
openaire +2 more sources