Results 171 to 180 of about 290,024 (350)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

A population-based analysis of immunosuppression therapy after organ transplantation. [PDF]

BMC Health Serv Res
Hörbrand F, Stahn D, Killian P, Weichenberger L, Böhler D, Bramlage P.   +5 more
europepmc   +1 more source

Iatrogenic Alterations of Immunologic Surveillance in Man and Their Influence on Malignancy [PDF]

, 1971
Agosin M., Albert D., Alford T. C, Allison A. C, Alpert E., Alpert M. E., Anigsten L., Bach F. H., Baserga R., Bekkum D. W., Berman C., Bortin M. M., Bremberg S., Burnet F. M., Burnet F. M., Burnet F. M., Burnet F. M., Casey T. P., Davis R. C., Dent P. B., Deodhar S. D., Doak P. B., Doll R., Epstein R. B., Fisher E. R., Foley E. J., Foley E. J., Fortner J. G., Grant G. A., Gustafson E. G., Hellman K., Hirsch M. S., Huber J., Immunology and Cancer, Isojima S., Jensen C O., Kay S., Law L. W., MacLean L. D., Mandel M.A., Marchioro T. L., Martin D. C, Martinez C, Mathe G., Mathe G., McIntosh D. A., McKhann C. F., Miller J. F. A. P., Moore G. E., Muizniks H. W., Page A. R., Penn I., Penn I., Penn I., Penn I., Prehn R. T., Pritzker K. P. H., Rabbat A. G., Santos G. W., Santos G. W., Schwartz R., Simmons R. L., Sjogren H. O., Snell G. D., Southam C. M., Speck B., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Tallent M. B., Thomas L., Toolan H.W., Tunner W. S., Tyler A., Vredevoe D. L., Weiler E., Wilson R. E., Zukoski C. F., Zukoski C. F.   +85 more
core   +1 more source

0379 Survival implications of systemic immunosuppression timing, dosage, and duration in immune checkpoint inhibitor therapy: A retrospective multicohort study [PDF]

Guibin Wan, Nga Nguyen, Charles Lu, Sara Khattab, Boshen Yan, M. Amadife, Bonnie Leung, W. Chen, S. Kwatra, K. Reynolds, Nicole R. LeBoeuf, A. Gusev, Y. Semenov   +12 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Compatibility of Post-Kidney Transplant Immunosuppression Therapy with Lactation. [PDF]

J Clin Med
Gomez-Casado G, Alonso-Titos J, Gonzalez-Mesa E, Ortega-Gomez A.   +3 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source