Results 181 to 190 of about 213,546 (300)

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Management of Norovirus Infection in Solid Organ Transplant Recipients: A Scoping Review. [PDF]

Transplant Direct
Maung Myint T, Hand J, Lowe A, Kotton CN, Chen SC, Beardsley J, Teixeira-Pinto A, Wong G, Chan S.   +8 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

New Monitoring Method Using Flow Cytometry for Evaluating Immunosuppression in Transplant Patients with Multiple Combination Therapy

The combination therapy of carcinurin inhibitor (CNI), and inhibitor of nucleic acid production, has been widely utilized in clinical kidney transplantation. Mycophenolate mofetil (MMF) has a strong immunosuppressive effect as compared with azathioprine.
1689, 1688, 1693, 1692, Koyama, Isamu, 1691, 1690, Asano, Hiroshi, Ogawa, Nobuji, 小川, 展二, 小山, 勇, 淺野, 博   +11 more
core  

Infections in Patients With Cytokine Release Syndrome/Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T-Cell Therapy. [PDF]

Open Forum Infect Dis
Gallardo-Pizarro A, Ariño M, Lopera C, Martinez-Urrea A, Terrones-Campos C, Castiella-Aranzasti A, González-Navarro EA, Albiol N, Teijon-Lumbreras C, Pitart C, Marcos MÁ, Ortíz-Maldonado V, Mensa J, Delgado J, Urbano-Ispizua Á, Fernández de Larrea C, Soriano A, Martinez-Cibrian N, Castro P, Garcia-Vidal C.   +19 more
europepmc   +1 more source

Immunosuppression therapy in the management of peripartum cardiomyopathy: A case series and literature review. [PDF]

Obstet Med, 2016
Basu J, Redman C, Ormerod O.
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Association of Urinary Soluble CD163 With Response to Immunosuppressive Therapy and Renal Relapse in IgAN. [PDF]

Kidney Int Rep
Zhao H, Zhan Z, Lin T, Pan Y, Yuan S, Huang J, Jia L, Xie D.   +7 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source