Results 211 to 220 of about 269,737 (365)

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

The development of immunosuppression in the renal model [PDF]

, 1984
Iwatsuki, S, Shaw, BW, Starzl, TE
core  

Studies on transplantation [PDF]

, 1967
Iwasaki, Y, Kashiwagi, N, Marchioro, TL, Starzl, TE   +3 more
core   +1 more source

Long‐term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy

, 2018
Javier Villadiego, Sonia Romo‐Madero, Roberto García‐Swinburn, Nela Suárez‐Luna, Alfonso Bermejo‐Navas, Miriam Echevarrı́a, Juan José Toledo‐Aral   +6 more
openalex   +1 more source

Convertible ROS Nanocatalyst/Eliminator for Enhancing Tumor Radio‐Immunotherapy and Relieving Radiation Enteritis

Advanced Science, EarlyView.
A novel Janus Ag/Ag2S nanostructure grafted with dimer PD‐L1 affibody (AMZ) is successfully developed. AMZ can be used as ROS nanocatalyst to achieve tumor radiosensitization, and it can also act as an ROS eliminator to alleviate radiation enteritis, achieving a radiotherapy strategy characterized by “toxicity reduction and efficacy enhancement ...
Mengmeng Zhang, Xinyu Zhang, Chenyu Wang, Mengyao Mu, Ke Ren, Nengyi Ni, Li Xian Yip, Kai Guo, Xiaoyu Hu, Feifei Teng, David Tai Leong, Qing Fan, Xiao Sun   +12 more
wiley   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

Advocating for the recognition of underlying immunosuppression in critical illness. [PDF]

EClinicalMedicine
Martin-Loeches I, David S, Pène F, Kreitmann L, Russel L, Puxty K, Silva JS, Mata AV, Creagh-Brown B, Castro P, Salluh J, Vidaur-Tello L, Nseir S, Azoulay E.   +13 more
europepmc   +1 more source

Exposure of a patient with systemic lupus erythematosus, under immunosuppression therapy, to human immunodeficiency virus by accidental needlestick contamination

, 2018
Ana Vanderley Oliveira, Licia M. da Mota, Jozélio Freire de Carvalho, Roberto Correia Araujo, Leopoldo Luiz dos Santos‐Neto   +4 more
openalex   +2 more sources

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

Low Absolute Lymphocyte Count Associated With Anti-Thymocyte Globulin Induction May Be a Predictor of Early Cytomegalovirus Infection in Pediatric Heart Transplantation. [PDF]

Pediatr Transplant
Chan A, Tan R, Tan S, Kuhn M, Shwaish N, Chinnock R, Tran H, Frandsen E.   +7 more
europepmc   +1 more source