Results 211 to 220 of about 290,024 (350)

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Bone complications after hand and face transplantation: Mechanisms and management. [PDF]

JPRAS Open
Dirican O, Sazoglu B, Demir Z, Kodali NA, Janarthanan R, Kulahci Y, Zor F, Gorantla VS.   +7 more
europepmc   +1 more source

Late Treatment With Autologous Expanded Regulatory T-cell Therapy After Alemtuzumab Induction Is Safe and Facilitates Immunosuppression Minimization in Living Donor Renal Transplantation

Matthew O. Brook, Conor Hennessy, Joanna Hester, Salim Hammad, Alaa Alzhrani, Ines Rombach, Susan Dutton, Giovanna Lombardi, Kathryn J. Wood, Peter J. Friend, Paul Harden, Fadi Issa   +11 more
openalex   +1 more source

EFFECT OF THE DEGREE OF IMMUNOSUPPRESSION AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON SERUM IL-17 AND IL-10 LEVEL IN PATIENTS WITH HIV-INFECTION

, 2013
D. H. Zhyvytsia
openalex   +2 more sources

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Refractory Dermatophytosis and Oral Hairy Leukoplakia as Sentinel Manifestations of Advanced HIV Infection. [PDF]

Cureus
Douvali T, Vasalou V, Gregoriou S, Stratigos A, Nicolaidou E.   +4 more
europepmc   +1 more source

Incidence of fistulas following human pancreas transplantation [PDF]

, 1987
Abendroth, D., Gottwald, T., Illner, Wolf-Dieter, Land, Walter   +3 more
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Checkpoint inhibitor effectiveness after corticosteroids and second-line immunosuppressants for immune-related adverse events in non-small-cell lung cancer. [PDF]

ESMO Open
van Dijk EJ, Smeenk MM, Bensch F, Sadowksa AM, Verschueren MV, Verhaert M, Llobell A, Suzuki Y, Liew DFL, Takeji A, Maria ATJ, Peters BJM, Garcia Morillo JS, Chatzidionysiou K, Lidar M, van der Hout EC, Aspeslagh S, Herder GJM, van de Garde EMW, Hendriks LEL, Hijmering-Kappelle LBM, Theelen WSME, Suijkerbuijk KPM, Verheijden RJ.   +23 more
europepmc   +1 more source