Results 251 to 260 of about 269,737 (365)

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

Advanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen, Dunfang Liu, Jiahui Jin, Han Yao, Yao Sheng, Yarong Liu, Jingwei Sun, Yang Yang   +7 more
wiley   +1 more source

Concurrent Banff 2A Acute Cellular Rejection and BK Virus Nephropathy in a Kidney Transplant Recipient: A Case Report and Review of Management Strategies. [PDF]

Cureus
Jalalzadeh M, Cheng M.
europepmc   +1 more source

Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a review of definitions, potential therapies, and research priorities [PDF]

Karan R. Chadda, Zudin Puthucheary
openalex   +1 more source

PD‐L1‐Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan, Chengyu Shi, Guangyi Chi, Xinwan Su, Fangzhou Liu, Linyu Zhu, Guangqian Cheng, Xiangyi Chen, Meng Yu, Yijian Chen, Ying Wang, Yu Chen, ShuLing Yan, Wenfei Wu, Qingfeng Yan, Jianzhong Shao, Kai Wang, Xiangrui Liu, Min Zhou, Aifu Lin   +19 more
wiley   +1 more source

Adoptive Cell Immunotherapy in Relapse/Refractory Epstein-Barr Virus-Driven Post-Transplant Lymphoproliferative Disorders. [PDF]

Antibodies (Basel)
Canichella M, de Fabritiis P.
europepmc   +1 more source

Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection [PDF]

Yannik Vollmuth, Nicola Jungbäck, Tatiana Mögele, Friederike Schmidt‐Graf, Silke Wunderlich, Mareike Schimmel, Camilla Rothe, Leonhard Stark, Jürgen Schlegel, Georg Rieder, Thomas Richter, Tina Schaller, Dennis Tappe, Bruno Märkl, Kaspar Matiasek, Friederike Liesche‐Starnecker   +15 more
openalex   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Androgen deprivation therapy-resistant club cells are linked to myeloid cell-driven immunosuppression in the prostate tumor microenvironment [PDF]

Antti Kiviaho, Sini K. Eerola, Heini Kallio, Maria Andersen, Xander Spotbeen, Alexander Giesen, Charles Parker, Sinja Taavitsainen, Olli Hantula, Mikael Marttinen, Ismaïl Hermelo, Mazlina Ismail, Elise Midtbust, Maximilian Wess, Wout Devlies, Abhibhav Sharma, Sebastian Krossa, Tomi Häkkinen, Ebrahim Afyounian, Juha Kesseli, Teemu Tolonen, Teuvo L.J. Tammela, Trond Viset, Øystein Størkersen, Guro F. Giskeødegård, Morten Beck Rye, Teemu J. Murtola, Andrew Erickson, Leena Latonen, G. Steven Bova, Ian G. Mills, Steven Joniau, Johannes V. Swinnen, Thierry Voet, Tuomas Mirtti, Gerhardt Attard, Frank Claessens, Tapio Visakorpi, Kirsi J. Rautajoki, May‐Britt Tessem, Alfonso Urbanucci, Matti Nykter   +41 more
openalex   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

Corticosteroids in immunocompromised ICU patients with severe COVID-19: a multicenter retrospective study. [PDF]

Sci Rep
Dupuis C, Timsit JF, Domitile J, Klouche K, Calvet L, Neuville M, Siami S, Cohen Y, Laurent V, Mourvillier B, Goldgran-Toledano D, Schwebel C, Ruckly S, Meziani F, Raymond M, Dessap AM, Souweine B.   +16 more
europepmc   +1 more source