Advances in Immunosuppressive Agents Based on Signal Pathway [PDF]
Immune abnormality involves in various diseases, such as infection, allergic diseases, autoimmune diseases, as well as transplantation. Several signal pathways have been demonstrated to play a central role in the immune response, including JAK/STAT, NF ...
Zhiqing Xu, Zhiqing Xu, Ming Chu
doaj +2 more sources
Cardiovascular effects of immunosuppression agents
Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis ...
Aly Elezaby+4 more
doaj +3 more sources
Actinomycosis in a Mucosal Lesion on a Created Perioral Dimple: A Case Report [PDF]
Facial dimple creation is a simple surgical procedure. Nonetheless, several complications can occur. Actinomycosis is a rare chronic granulomatous infection caused by Actinomyces species.
Ui Geon Kim+3 more
doaj +1 more source
Immunosuppressive therapy in non-infections uveitis and retinovasculitis
Purpose: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.Methods: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 ...
E. A. Drozdova
doaj +3 more sources
Safety and effectiveness of mycophenolate mofetil associated with tacrolimus for liver transplantation immunosuppression: a systematic review and meta-analysis of randomized controlled trials [PDF]
A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation.
Francisco Tustumi+11 more
doaj +1 more source
Off-label use of rituximab in dermatology: pemphigus treatment [PDF]
Since its approval in 1997 by the FDA (United States Food and Drug Administration), rituximab has been used for certain B-cell lymphomas and treatment-resistant rheumatoid arthritis.
Lislaine Bomm+4 more
doaj +1 more source
New-onset epilepsy in a patient with myelin oligodendrocyte glycoprotein antibodies [PDF]
In the literature, several adult cases with myelin oligodendrocyte glycoprotein (MOG) antibodies (Abs)-associated disorders have been reported to have seizure and acute disseminated encephalomyelitis (ADEM) as the main clinical manifestations, but the ...
Hansol Im, Taewon Kim
doaj +1 more source
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil [PDF]
The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used.
Stephanie Del Rio Navarrete Biot+5 more
doaj +1 more source
New drugs, new challenges for dermatologists: mucocutaneous ulcers secondary to everolimus [PDF]
Everolimus, a mammalian target of rapamycin inhibitor, is an emerging drug, which is being increasingly applied in oncology and solid organ transplantation. Oral ulcers are a frequent side effect associated with this immunosupressor.
Victor Pavan Pasin+5 more
doaj +1 more source
Rituximab: A Magic Bullet for Pemphigus [PDF]
Introduction: Pemphigus, an autoimmune disease, was fatal before the era of corticosteroids. With the advent of steroids, mortality decreased but morbidity was present due to the side effects of high dose steroids.
V. Anandan+4 more
doaj +1 more source